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dc.contributor.authorPetacci, Fernando-
dc.contributor.authorFreitas, Silvia S.-
dc.contributor.authorBrunetti, Iguatemy Lourenço-
dc.contributor.authorKhalil, Najeh M.-
dc.identifier.citationBiological Research. Santiago: Soc Biolgia Chile, v. 43, n. 1, p. 63-74, 2010.-
dc.description.abstractAstilbin (5,7,3',4'-tetrahydroxy-2,3-dihydroflavonol-3-beta-o-rhamnoside), a flavonoid with a large range of biological activities, was isolated from Dimorphandra molls, a shrub common to the Brazilian Cerrado. The purpose of this study is to verify the effects of astilbin on myeloperoxidase (MPO) and horseradish peroxidase (HRP), and its antioxidant activity against hypochlorous acid (HOCl) and total antioxidant activity (TAC) by the 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS center dot+). Astilbin inhibited MPO and HRP activities in a concentration-dependent relationship and effectively scavenged HOC. The TAC by ABTS center dot+ of astilbin (IC50 similar to 20 mM) was higher than that of uric acid, which was used as a positive control. These data demonstrate that astilbin is a potent antioxidant and that it inhibits MPO and HRP activities efficiently.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherSoc Biolgia Chile-
dc.sourceWeb of Science-
dc.subjectHorseradish peroxidaseen
dc.subjectReactive Oxygen Speciesen
dc.subjectHypochlorous aciden
dc.titleInhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae)en
dc.contributor.institutionUniversidade Estadual do Centro Oeste (UNICENTRO)-
dc.contributor.institutionUniversidade Federal de Goiás (UFG)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationGuararapuava UNICENTRO, Dept Pharm, Guararapuava, Para, Brazil-
dc.description.affiliationCAC UFG, Dept Chem, Catalao, Go, Brazil-
dc.description.affiliationSão Paulo State Univ, UNESP, Clin Anal Dept, Sch Pharmaceut Sci, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Clin Anal Dept, Sch Pharmaceut Sci, São Paulo, Brazil-
dc.description.sponsorshipIdCNPq: 475879/2008-2-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBiological Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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