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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/72569
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dc.contributor.authorNwidu, Lucky Lebgosi-
dc.contributor.authorNwafor, Paul Alozie-
dc.contributor.authorDa Silva, Viviane Cândida-
dc.contributor.authorRodrigues, Clenilson Martins-
dc.contributor.authorSantos, Lourdes Campaner dos-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorNunes-De-Souza, Ricardo Luiz-
dc.date.accessioned2014-05-27T11:25:57Z-
dc.date.accessioned2016-10-25T18:34:13Z-
dc.date.available2014-05-27T11:25:57Z-
dc.date.available2016-10-25T18:34:13Z-
dc.date.issued2011-08-01-
dc.identifierhttp://dx.doi.org/10.1007/s10787-010-0076-y-
dc.identifier.citationInflammopharmacology, v. 19, n. 4, p. 215-225, 2011.-
dc.identifier.issn0925-4692-
dc.identifier.issn1568-5608-
dc.identifier.urihttp://hdl.handle.net/11449/72569-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/72569-
dc.description.abstractLeaves from Carpolobia lutea (Polygalaceae) were screened to establish the antiulcer ethnomedicinal claim and to quantitatively isolate, elucidate the active compounds by semi-preparative HPLC. The anti-nociceptive effects of Carpolobia lutea (CL) G. Don (Polygalaceae) organic leaf extracts were tested in experimental models in mice. The anti-nociceptive mechanism was determined using tail-flick test, acetic acid-induced abdominal constrictions, formalin-induced hind paw licking and the hot plate test. The fractions (ethanol, ethyl acetate, chloroform, n-hexane) and crude ethyl acetate extract of CL (770 mg/kg, i.p.) produced significant inhibitions of both phases of the formalin-induced pain in mice, a reduction in acetic acid-induced writhing as well as and an elevation of the pain threshold in the hot plate test in mice. The inhibitions were greater to those produced by indomethacin (5 mg/kg, i.p.). Ethyl acetate fraction revealed cinnamic and coumaric acids derivatives, which are described for the first time in literature. These cinnamalglucosides polyphenols characterised from CL may in part account for the pharmacological activities. These findings confirm its ethnomedical use in anti-inflammatory pain and in pains from gastric ulcer-associated symptoms. © 2011 Springer Basel AG.en
dc.format.extent215-225-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAntinociceptive-
dc.subjectCarpolobia lutea-
dc.subjectHPLC isolation of cinnamalglucosides-
dc.subjectPolygalaceae-
dc.subject4 coumaroyl 1 deoxyglucopyranoside derivative-
dc.subjectacetic acid-
dc.subjectacetic acid ethyl ester-
dc.subjectalcohol-
dc.subjectantinociceptive agent-
dc.subjectatropine-
dc.subjectCarpolobia lutea extract-
dc.subjectchloroform-
dc.subjectcinnamic acid-
dc.subjectcinnamic acid derivative-
dc.subjectcinnamoyl 1 deoxyglucopyranoside derivative-
dc.subjectcoumaric acid-
dc.subjectdimorf-
dc.subjectformaldehyde-
dc.subjecthexane-
dc.subjectindometacin-
dc.subjectmorphine sulfate-
dc.subjectnaltrexone-
dc.subjectplant extract-
dc.subjectunclassified drug-
dc.subjectabdominal pain-
dc.subjectanalgesic activity-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectantinociception-
dc.subjectcontrolled study-
dc.subjectdrug isolation-
dc.subjectdrug screening-
dc.subjectdrug structure-
dc.subjectfemale-
dc.subjectfoot pain-
dc.subjecthot plate test-
dc.subjectlicking-
dc.subjectmale-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpain-
dc.subjectpain threshold-
dc.subjectplant leaf-
dc.subjectpriority journal-
dc.subjecttail flick test-
dc.subjectwrithing test-
dc.subjectAbdominal Pain-
dc.subjectAnalgesics, Non-Narcotic-
dc.subjectAnimals-
dc.subjectAnti-Inflammatory Agents, Non-Steroidal-
dc.subjectBehavior, Animal-
dc.subjectCinnamates-
dc.subjectCoumaric Acids-
dc.subjectDrug Discovery-
dc.subjectFemale-
dc.subjectGlucosides-
dc.subjectHot Temperature-
dc.subjectLethal Dose 50-
dc.subjectMale-
dc.subjectMedicine, African Traditional-
dc.subjectMice-
dc.subjectMolecular Structure-
dc.subjectNigeria-
dc.subjectPain Measurement-
dc.subjectPlant Extracts-
dc.subjectPlant Leaves-
dc.titleAnti-nociceptive effects of Carpolobia lutea G. Don (Polygalaceae) leaf fractions in animal modelsen
dc.typeoutro-
dc.contributor.institutionNiger Delta University-
dc.contributor.institutionUniversity of Uyo-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Pharmacology and Toxicology Faculty of Pharmacy Niger Delta University, Wilberforce Island, Bayelsa State-
dc.description.affiliation, P.O. Box 10935, Port Harcourt, Rivers State-
dc.description.affiliationDepartment of Pharmacology and Toxicology Faculty of Pharmacy University of Uyo, Uyo, Akwa Ibom State-
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química UNESP, Univ. Estadual Paulista, CP 355, Araraquara, SP CEP 14801-970-
dc.description.affiliationLab. Farmacologia Faculdade de Ciencias UNESP, Araraquara-jau, km 01, Araraquara, SP 14801-902-
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química UNESP, Univ. Estadual Paulista, CP 355, Araraquara, SP CEP 14801-970-
dc.description.affiliationUnespLab. Farmacologia Faculdade de Ciencias UNESP, Araraquara-jau, km 01, Araraquara, SP 14801-902-
dc.identifier.doi10.1007/s10787-010-0076-y-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInflammopharmacology-
dc.identifier.scopus2-s2.0-79960245702-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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