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http://acervodigital.unesp.br/handle/11449/72626
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DC Field | Value | Language |
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dc.contributor.author | Franco Junior, Jose Gonçalves | - |
dc.contributor.author | Oliveira, Joao Batista A | - |
dc.contributor.author | Petersen, Claudia G | - |
dc.contributor.author | Mauri, Ana L. | - |
dc.contributor.author | Baruffi, Ricardo LR | - |
dc.contributor.author | Cavagna, Mario | - |
dc.date.accessioned | 2014-05-27T11:25:58Z | - |
dc.date.accessioned | 2016-10-25T18:34:22Z | - |
dc.date.available | 2014-05-27T11:25:58Z | - |
dc.date.available | 2016-10-25T18:34:22Z | - |
dc.date.issued | 2011-09-01 | - |
dc.identifier | http://www.jbra.com.br/mensagem/pub/mensagem.php?id_mensagem=custom_arquive&lingua_atual=_ing | - |
dc.identifier.citation | Jornal Brasileiro de Reproducao Assistida, v. 15, n. 5, p. 39-43, 2011. | - |
dc.identifier.issn | 1517-5693 | - |
dc.identifier.issn | 1518-0557 | - |
dc.identifier.uri | http://hdl.handle.net/11449/72626 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/72626 | - |
dc.description.abstract | Infertility represents one of the main long-term consequences of combination chemotherapy used for the treatment of breast cancer. Approximately 60%-65% of breast cancers express the nuclear hormone receptor in premenopausal women. Adjuvant endocrine therapy is an integral component of care for patients with hormone receptor-positive (HR+) tumours. The GnRH agonist (GnRHa) alone or in combination with tamoxifen produces results at least similar to those obtained with the different chemotherapy protocols in patients with HR+ tumors with respect to recurrence-free survival and overall survival, Presentation of the hypothesis: It is time to indicate adjuvant therapy with GnRHa associated with tamoxifen for patients with breast cancer (HR+ tumours) if they want to preserve their reproductive function. Testing the hypothesis: Assessment of ovarian reserve tests: follicle stimulating hormone (FSH), anti-Mullerian hormone (AMH), inhibin B, antral follicle count (AFC) and ovarian volume 6 months, and 1 year after the end of therapy with GnRHa/tamoxifen. The recurrence-free survival and overall survival should be analysed. Implications of the hypothesis: The major implication will be to avoid adjuvant chemotherapy for patients with breast cancer (HR+ tumours) that request fertility preservation. It is expected that ovarian function should not be altered in almost all cases. © Todos os direitos reservados a SBRA - Sociedade Brasileira de Reprodução Assistida. | en |
dc.format.extent | 39-43 | - |
dc.language.iso | eng | - |
dc.language.iso | por | - |
dc.source | Scopus | - |
dc.subject | Adjuvant therapy | - |
dc.subject | Breast cancer | - |
dc.subject | Chemotherapy | - |
dc.subject | Fertility preservation | - |
dc.subject | GnRHa | - |
dc.subject | Hormone receptor-positive | - |
dc.subject | Tamoxifen | - |
dc.subject | Cyclophosphamide | - |
dc.subject | Fluorouracil | - |
dc.subject | Follitropin | - |
dc.subject | Gonadorelin agonist | - |
dc.subject | Hormone receptor | - |
dc.subject | Inhibin B | - |
dc.subject | Methotrexate | - |
dc.subject | Muellerian inhibiting factor | - |
dc.subject | Tamoxifen | - |
dc.subject | Adjuvant therapy | - |
dc.subject | Amenorrhea | - |
dc.subject | Breast cancer | - |
dc.subject | Disease association | - |
dc.subject | Disease free survival | - |
dc.subject | Fertility | - |
dc.subject | Human | - |
dc.subject | Hypergonadotropism | - |
dc.subject | Ovarian reserve | - |
dc.subject | Ovary function | - |
dc.subject | Ovary insufficiency | - |
dc.subject | Overall survival | - |
dc.subject | Reproduction | - |
dc.title | Adjuvant therapy with GnRH agonists/tamoxifen in breast cancer should be a good council for patients with hormone receptor-positive tumours and wish to preserve fertility | en |
dc.title.alternative | A terapêutica adjuvante com agonista do GnRH/tamoxifeno no cancer de mama pode ser um bom conselho para os pacientes com tumors receptor-hormonal positivos e desejo de preservar a fertilidade | pt |
dc.type | outro | - |
dc.contributor.institution | Center for Human Reproduction | - |
dc.contributor.institution | Research and Training | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Center for Human Reproduction, Ribeirao Preto | - |
dc.description.affiliation | Paulista Center for Diagnosis Research and Training, Ribeirao Preto | - |
dc.description.affiliation | Department of Gynecology and Obstetrics Botucatu Medical School São Paulo State University - UNESP, Botucatu | - |
dc.description.affiliationUnesp | Department of Gynecology and Obstetrics Botucatu Medical School São Paulo State University - UNESP, Botucatu | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Jornal Brasileiro de Reproducao Assistida | - |
dc.identifier.scopus | 2-s2.0-80052392800 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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