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DC Field | Value | Language |
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dc.contributor.author | de Matos, Djamile Cordeiro | - |
dc.contributor.author | Abreu de Ribeiro, Livia Carolina | - |
dc.contributor.author | Tansini, Aline | - |
dc.contributor.author | Ferreira, Lucas Souza | - |
dc.contributor.author | Polesi Placeres, Marisa Campos | - |
dc.contributor.author | Luis Colombo, Lucas | - |
dc.contributor.author | Carlos, Iracilda Zeppone | - |
dc.date.accessioned | 2014-05-20T13:23:52Z | - |
dc.date.available | 2014-05-20T13:23:52Z | - |
dc.date.issued | 2012-07-24 | - |
dc.identifier | http://dx.doi.org/10.1186/1472-6882-12-107 | - |
dc.identifier.citation | Bmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 12, p. 6, 2012. | - |
dc.identifier.issn | 1472-6882 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7269 | - |
dc.description.abstract | Background: Ribosome-inactivating proteins (RIP) have been studied in the search for toxins that could be used as immunotoxins for cancer treatment. Pulchellin, a type 2 RIP, is suggested to induce immune responses that have a role in controlling cancer.Methods: The percentage of dendritic cells and CD4(+) and CD8(+) T cells in the spleen (flow cytometry), cytokines' release by PECs and splenocytes (ELISA) and nitric oxide production by PECs (Griess assay) were determined from tumor-bearing mice injected intratumorally with 0.1 ml of pulchellin at 0.75 mu g/kg of body weight. Statistical analysis was performed by one-way ANOVA with Tukey's post hoc test.Results: Pulchellin-treated mice showed significant immune system activation, characterized by increased release of IFN-gamma and Th2 cytokines (IL-4 and IL-10), while IL-6 and TGF-beta levels were decreased. There was also an increase in macrophage's activation, as denoted by the higher percentage of macrophages expressing adhesion and costimulatory molecules (CD54 and CD80, respectively).Conclusions: Our results suggest that pulchellin is promising as an adjuvant in breast cancer treatment. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 6 | - |
dc.language.iso | eng | - |
dc.publisher | Biomed Central Ltd. | - |
dc.source | Web of Science | - |
dc.subject | Pulchellin | en |
dc.subject | Breast cancer | en |
dc.subject | Cytokines | en |
dc.subject | Immune system | en |
dc.title | Immunological response in mice bearing LM3 breast tumor undergoing Pulchellin treatment | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Buenos Aires | - |
dc.description.affiliation | São Paulo State Univ, Clin Immunol Lab, Sch Pharmaceut Sci, São Paulo, Brazil | - |
dc.description.affiliation | Univ Buenos Aires, Inst Oncol Angel H Roffo, Buenos Aires, DF, Argentina | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ, Clin Immunol Lab, Sch Pharmaceut Sci, São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
dc.identifier.doi | 10.1186/1472-6882-12-107 | - |
dc.identifier.wos | WOS:000310323800001 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000310323800001.pdf | - |
dc.relation.ispartof | BMC Complementary and Alternative Medicine | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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