You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/72784
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRochel-Maia, Sabrina S.-
dc.contributor.authorSantos, Fernanda C. A.-
dc.contributor.authorVilamaior, Patrícia S. L.-
dc.contributor.authorJustulin Jr., Luis A.-
dc.contributor.authorFelisbino, Sérgio L.-
dc.contributor.authorGóes, Rejane M.-
dc.contributor.authorTaboga, Sebastião R.-
dc.date.accessioned2014-05-27T11:26:06Z-
dc.date.accessioned2016-10-25T18:35:00Z-
dc.date.available2014-05-27T11:26:06Z-
dc.date.available2016-10-25T18:35:00Z-
dc.date.issued2011-11-01-
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21938680-
dc.identifier.citationHistology and Histopathology, v. 26, n. 11, p. 1423-1434, 2011.-
dc.identifier.issn0213-3911-
dc.identifier.urihttp://hdl.handle.net/11449/72784-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/72784-
dc.description.abstractTIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with testosterone for 7 or 21 days, were submitted to histological, stereological and immunohistochemical analyses. Stereology of prostatic components showed significant alterations of tissue compartments in the ventral male prostate after castration, especially after 21 days, with a significant increase in stroma. Administration of testosterone led to disorganization in the female prostate, with a significant increase in collagen fibers and smooth muscle cells after 21 days, along with the development of epithelial lesions such as PINs. MMP-2 increased after 21 days of castration in males; however, the TIMP-2 immunoreaction for this group was weak or absent. In females, the expression of MMP-2 appeared to decrease after 7 days of treatment with testosterone, but after 21 days, both epithelium and stroma showed a stronger reaction for MMP-2 than the controls. The expression of TIMP-2 in the treated females was similar to its expression in the castrated males. We conclude that the distribution of MMPs and TIMPs in both male and female prostates is altered by androgen manipulation, but the mechanism of stromal regulation appears to be distinct between genders because both the lack of T in castrated males and the excess levels of T in treated females lead to the same effect.en
dc.format.extent1423-1434-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectFemale prostate-
dc.subjectMMP-
dc.subjectTestosterone-
dc.subjectTIMP-
dc.subjectVentral prostate-
dc.subjectandrogen-
dc.subjectgelatinase A-
dc.subjecttestosterone-
dc.subjecttissue inhibitor of metalloproteinase 2-
dc.subjectanimal-
dc.subjectdrug effect-
dc.subjectenzymology-
dc.subjectfemale-
dc.subjectgerbil-
dc.subjectimmunohistochemistry-
dc.subjectmale-
dc.subjectmetabolism-
dc.subjectorchiectomy-
dc.subjectprostate-
dc.subjectsexual development-
dc.subjectAndrogens-
dc.subjectAnimals-
dc.subjectFemale-
dc.subjectGerbillinae-
dc.subjectImmunohistochemistry-
dc.subjectMale-
dc.subjectMatrix Metalloproteinase 2-
dc.subjectOrchiectomy-
dc.subjectProstate-
dc.subjectSex Characteristics-
dc.subjectTissue Inhibitor of Metalloproteinase-2-
dc.subjectMeriones unguiculatus-
dc.titleMMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: Effects of hormonal manipulationen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal de Goiás (UFG)-
dc.contributor.institutionUniversidade Federal do Triângulo Mineiro (UFTM)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Cell Biology Institute of Biology State University of Campinas (UNICAMP), São Paulo-
dc.description.affiliationDepartment of Morphology Institute of Biology Sciences Federal University of Goiás (UFG), Goiás-
dc.description.affiliationDepartment of Morphology Federal University of Triângulo Mineiro-UFTM, Uberaba, Minas Gerais-
dc.description.affiliationDepartment of Morphology-Institute of Biosciences (IBB) São Paulo State University (UNESP), São Paulo-
dc.description.affiliationDepartment of Biology Institute of Biosciences, Humanities, and Exact Sciences (IBILCE) São Paulo State University (UNESP), São Paulo-
dc.description.affiliationUnespDepartment of Morphology-Institute of Biosciences (IBB) São Paulo State University (UNESP), São Paulo-
dc.description.affiliationUnespDepartment of Biology Institute of Biosciences, Humanities, and Exact Sciences (IBILCE) São Paulo State University (UNESP), São Paulo-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-80053181072.pdf-
dc.relation.ispartofHistology and Histopathology-
dc.identifier.scopus2-s2.0-80053181072-
dc.identifier.orcid0000-0002-0970-4288pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.