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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/72899
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dc.contributor.authorRezende, Tiago M.-
dc.contributor.authorSponton, Carlos H.G.-
dc.contributor.authorMalagrino, Pamella A.-
dc.contributor.authorBezerra, Marcos A.C.-
dc.contributor.authorPenteado, Carla F.F.-
dc.contributor.authorZanesco, Angelina-
dc.date.accessioned2014-05-27T11:26:15Z-
dc.date.accessioned2016-10-25T18:35:58Z-
dc.date.available2014-05-27T11:26:15Z-
dc.date.available2016-10-25T18:35:58Z-
dc.date.issued2011-12-01-
dc.identifierhttp://dx.doi.org/10.3109/13813455.2011.596548-
dc.identifier.citationArchives of Physiology and Biochemistry, v. 117, n. 5, p. 265-269, 2011.-
dc.identifier.issn1381-3455-
dc.identifier.issn1744-4160-
dc.identifier.urihttp://hdl.handle.net/11449/72899-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/72899-
dc.description.abstractContext: Presence of endothelial nitric oxide synthase (eNOS) gene polymorphism has been associated with cardiovascular disease (CVD) whereas exercise training (EX) promotes beneficial effects on CVD which is related to increased nitric oxide levels (NO). Objective: To evaluate if women with eNOS gene polymorphism at position-G894T would be less responsive to EX than those who did not carry T allele. Methods: Women were trained 3 days/week, 40 minutes session during 6 months. Cardio-biochemical parameters and genetic analysis were performed in a double-blind fashion. Results: Plasma NOx - levels were similar in both groups at baseline (GG genotype: 18.44±3.28 μM) and (GT + TT genotype: 17.19±2.43 μM) and after EX (GG: 29.20±4.33 and GT+TT: 27.38±3.12 μM). A decrease in blood pressure was also observed in both groups. Discussion and conclusion: The presence of eNOS polymorphism does not affect the beneficial effects of EX in women. © 2011 Informa UK, Ltd.en
dc.format.extent265-269-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectBlood pressure-
dc.subjectNitric oxide-
dc.subjectPhysical training-
dc.subjectWomen-
dc.subjectendothelial nitric oxide synthase-
dc.subjectnitric oxide-
dc.subjectNOS3 protein, human-
dc.subjectallele-
dc.subjectbiosynthesis-
dc.subjectblood-
dc.subjectblood pressure-
dc.subjectBrazil-
dc.subjectcardiovascular disease-
dc.subjectcase control study-
dc.subjectdouble blind procedure-
dc.subjectenzymology-
dc.subjectexercise-
dc.subjectfemale-
dc.subjectgene frequency-
dc.subjectgenetics-
dc.subjectgenotype-
dc.subjecthuman-
dc.subjectmiddle aged-
dc.subjectsingle nucleotide polymorphism-
dc.subjectAlleles-
dc.subjectBlood Pressure-
dc.subjectCardiovascular Diseases-
dc.subjectCase-Control Studies-
dc.subjectDouble-Blind Method-
dc.subjectExercise-
dc.subjectFemale-
dc.subjectGene Frequency-
dc.subjectGenotype-
dc.subjectHumans-
dc.subjectMiddle Aged-
dc.subjectNitric Oxide-
dc.subjectNitric Oxide Synthase Type III-
dc.subjectPolymorphism, Single Nucleotide-
dc.titleEffect of exercise training on the cardiovascular and biochemical parameters in women with eNOS gene polymorphismen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationLaboratory of Cardiovascular Research and Physical Activity Institute of Bioscience University of São Paulo State (UNESP), Rio Claro (SP)-
dc.description.affiliationHematology and Hemotherapy Center School of Medicine UNICAMP, Campinas (SP)-
dc.description.affiliationUnespLaboratory of Cardiovascular Research and Physical Activity Institute of Bioscience University of São Paulo State (UNESP), Rio Claro (SP)-
dc.identifier.doi10.3109/13813455.2011.596548-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchives of Physiology and Biochemistry-
dc.identifier.scopus2-s2.0-82455171766-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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