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dc.contributor.authorPepato, Maria Teresa-
dc.contributor.authorAlberconi, Mayara F.-
dc.contributor.authorda Rocha, Michelle C.-
dc.contributor.authorVendramini, Regina Célia-
dc.contributor.authorBrunetti, Iguatemy Lourenço-
dc.contributor.authorBatista, Alzir A.-
dc.contributor.authorde Souza, Elizeu J.-
dc.contributor.authorGarcia, Edgardo-
dc.contributor.authorDeflon, Victor M.-
dc.identifier.citationTransition Metal Chemistry. Dordrecht: Springer, v. 33, n. 3, p. 301-309, 2008.-
dc.description.abstractA new vanadium (IV) complex with the monoanion of 2,3-dihydroxypyridine (H(2)dhp), or 3-hydroxy-2(1H)-pyridone, was synthesized, characterized by physicochemical techniques and tested biologically. The EPR data for the [VO(Hdhp)(2)] complex in DMF are: g(x) = 1.9768, g(y) = 1.9768 and g(z) = 1.9390; A values (10(-4) cm(-1)): A(x), 59.4; A(y//), 59.4; A(z), 171.0. The vV=O band in the IR spectrum of the complex is at 986 cm(-1). The complex is paramagnetic, with mu(eff) = 1.65 BM (d(1), spin-only) at 25 degrees C. The irreversible oxidation process [V(V)/V(IV)] of the [VO(Hdhp)(2)] complex, as revealed in a cyclic voltammogram, occurs at 876 mV. The calculated molecular structure of [VO(Hdhp)(2)] shows the vanadium(IV) center in a distorted square pyramidal environment, with the oxo ligand in the apical position and the oxygen donor atoms of the Hdhp ligands in the basal positions. The ability of [VO(Hdhp)(2)] to mimic insulin, and its toxicity to hepato-biliary functions, were investigated in streptozotocin-induced diabetic rats and it was concluded that the length of treatment and the amount of [VO(Hdhp)(2)] administered were effective in reducing experimental diabetes.en
dc.sourceWeb of Science-
dc.titleSynthesis, characterization and biological analysis of the complex [VO(Hdhp)(2)] (H(2)dhp=2,3-dihydroxypyridine)en
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionUniversidade de Brasília (UnB)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Aanl Clin, Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13560 São Carlos, SP, Brazil-
dc.description.affiliationUniversidade de Brasilia (UnB), Inst Quim, Brasilia, DF, Brazil-
dc.description.affiliationUniv São Paulo, Inst Quim, São Carlos, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Aanl Clin, Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofTransition Metal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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