You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorAlegranci, Pamela-
dc.contributor.authorde Mattos, Luiz C.-
dc.contributor.authorde Godoy, Moacir F.-
dc.contributor.authorMoreira, Haroldo Wilson-
dc.identifier.citationArchives of Medical Science. Poznan: Termedia Publishing House Ltd, v. 5, n. 1, p. 32-37, 2009.-
dc.description.abstractIntroduction: Haptoglobin polymorphism has been correlated with disease and some studies have associated the Hp(2) allele with susceptibility to or protection against certain infectious (pulmonary tuberculosis, HIV) and non-infectious (diabetes, coronary artery disease, obesity) diseases. The aim of this study was to verify possible correlations of haptoglobin genotypes and subtypes by comparing coronary artery disease (CAD) patients with blood donors.Material and methods: Haptoglobin genotypes and subtypes were analyzed by DNA amplification with the Dral restriction enzyme, in 125 CAD patients diagnosed by coronary angiography, and 125 blood donors as matched healthy controls.Results: The distribution of haptoglobin genotypes was similar in the groups, without significant statistical differences (p = 0.643). The Hp(2)/Hp(2) genotype was more frequent in both the CAD group and blood donors followed by Hp(2)/Hp(1) and Hp(1)/Hp(1). The allele frequency of Hp2 was higher than Hp(1) in the groups. The results showed a significant difference (p = 0.002) between the groups regarding haptoglobin subtypes; Hp(2FS)/Hp(2FS) was prevalent in both groups with the least frequent subtype being Hp(2FF)/Hp(2FF) for CAD patients and Hp(1F)/Hp(1S) among blood donors. There was a statistically significant difference (p = 0.027) between the frequencies of the commonest allele subtype, Hp(2FS), and the least common, Hp(2FF).Conclusions: Unlike blood donors, the Hp(2FF)/Hp(2FF) haptoglobin subtype was the least frequent among CAD patients, which may implicate this subtype in the development of CAD, a disease with a high mortality rate which consequently reduces the proportion of these individuals in populations.en
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherTermedia Publishing House Ltd-
dc.sourceWeb of Science-
dc.subjecthaptoglobin polymorphismen
dc.subjectcoronary artery diseaseen
dc.subjectblood donorsen
dc.subjectcorrelation with diseaseen
dc.titleHaptoglobin polymorphism correlated with coronary artery diseaseen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)-
dc.contributor.institutionSao Jose do Rio Preto Univ-
dc.description.affiliationUNESP, São Paulo State Univ, Sch Pharmaceut Sci, Dept Anal Clin,Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationSao Jose do Rio Preto Univ, Sch Med, Dept Cardiol & Vasc Surg, FAMERP, Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationUnespUNESP, São Paulo State Univ, Sch Pharmaceut Sci, Dept Anal Clin,Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFUNDUNESP: 0010507-
dc.description.sponsorshipIdCNPq: 134089/2006-5-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofArchives of Medical Science-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.