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dc.contributor.authorCarlos, Iracilda Zeppone-
dc.contributor.authorSassa, Micheli Fernanda-
dc.contributor.authorda Graca Sgarbi, Diana Bridon-
dc.contributor.authorPolesi Placeres, Marisa Campos-
dc.contributor.authorGeraldo Maia, Danielle Cardoso-
dc.identifier.citationMycopathologia. Dordrecht: Springer, v. 168, n. 1, p. 1-10, 2009.-
dc.description.abstractSporotrichosis is often manifested as a chronic granulomatous infection and the monocytes/macrophages play a central role in the host defense system. Surface components of Sporothrix schenckii have been characterized and suggestions have been made as to their possible role in pathogenicity. Ergosterol peroxide, cell-wall compounds (alkali-insoluble fraction-F1 and lipid extract-LEY), and exoantigen from the yeast form of the fungus have been characterized as virulence factors, activating both innate, by cytotoxins linked to the activation of reactive oxygen and nitrogen species (H(2)O(2) and NO), and adaptive immune response to produce cytokines Th1 and Th2 profile. In this study, preliminary results have demonstrated that, in systemic sporotrichosis, TLR-4 triggers the innate immune response, activating an oxidative burst. These data represent the first report of the participation of TLR-4 in murine sporotrichosis, in the presence of lipids from the cell wall of S. schenckii. These results taken together may open new perspectives of study leading to an antifungal agent that could be used to benefit the entire population.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipPrograma de Apoio ao Desenvolvimento Científico da Faculdade de Ciências Farmacêuticas da UNESP (PADC)-
dc.sourceWeb of Science-
dc.subjectSporothrix schenckiien
dc.subjectSystemic infectionen
dc.subjectNitric oxideen
dc.subjectHydrogen peroxideen
dc.subjectTh1/Th2 responseen
dc.titleCurrent Research on the Immune Response to Experimental Sporotrichosisen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal Fluminense (UFF)-
dc.description.affiliationUNESP, Univ Paulista, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, Araraquara, SP, Brazil-
dc.description.affiliationUniv Fed Fluminense, Inst Biomed, Dept Microbiol & Parasitol, Niteroi, RJ, Brazil-
dc.description.affiliationUnespUNESP, Univ Paulista, Dept Anal Clin, Fac Ciencias Farmaceut Araraquara, Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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