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dc.contributor.authorBonacorsi, Cibele-
dc.contributor.authorRaddi, Maria Stella G.-
dc.contributor.authorda Fonseca, Luiz Marcos-
dc.contributor.authorSannomiya, Miriam-
dc.contributor.authorVilegas, Wagner-
dc.identifier.citationInternational Journal of Molecular Sciences. Basel: Mdpi Ag, v. 13, n. 1, p. 133-141, 2012.-
dc.description.abstractByrsonima crassa Niedenzu (Malpighiaceae) is used in Brazilian folk medicine for the treatment of diseases related mainly to gastric ulcers. In a previous study, our group described the gastric protective effect of the methanolic extract from the leaves of B. crassa. The present study was carried out to investigate the effects of methanolic extract and its phenolic compounds on the respiratory burst of neutrophils stimulated by H. pylori using a luminol-based chemiluminescence assay as well as their anti-H. pylori activity. The suppressive activity on oxidative burst of H. pylori-stimulated neutrophils was in the order of methyl gallate > (+)-catechin > methanol extract > quercetin 3-O-alpha-L-arabinopyranoside > quercetin 3-O-beta-D-galactopyranoside > amentoflavone. Methyl gallate, compound that induced the highest suppressive activity with IC50 value of 3.4 mu g/mL, did not show anti-H. pylori activity. B. crassa could be considered as a potential source of natural antioxidant in gastric ulcers by attenuating the effects on the damage to gastric mucosa caused by neutrophil generated reactive oxygen species, even when H. pylori displays its evasion mechanisms.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherMdpi Ag-
dc.sourceWeb of Science-
dc.subjectByrsonima crassaen
dc.subjectHelicobacter pylorien
dc.subjectgastric ulcersen
dc.subjectantioxidant activityen
dc.subjectphenolic compoundsen
dc.titleEffect of Byrsonima crassa and Phenolic Constituents on Helicobacter pylori-Induced Neutrophils Oxidative Bursten
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationSão Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Sch Arts Sci & Humanities, BR-03828000 São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Chem, BR-14800900 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofInternational Journal of Molecular Sciences-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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