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http://acervodigital.unesp.br/handle/11449/74028
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DC Field | Value | Language |
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dc.contributor.author | Schwardt, Tatianna Frate | - |
dc.contributor.author | Vides, Juliana Peloi | - |
dc.contributor.author | Pacheco, Acácio Duarte | - |
dc.contributor.author | Langoni, Hélio | - |
dc.contributor.author | Generoso, Diego | - |
dc.contributor.author | Machado, Gisele Fabrino | - |
dc.contributor.author | Laurenti, Márcia Dalastra | - |
dc.contributor.author | Marcondes, Mary | - |
dc.date.accessioned | 2014-05-27T11:27:24Z | - |
dc.date.accessioned | 2016-10-25T18:40:34Z | - |
dc.date.available | 2014-05-27T11:27:24Z | - |
dc.date.available | 2016-10-25T18:40:34Z | - |
dc.date.issued | 2012-12-01 | - |
dc.identifier | http://www.revistas.usp.br/bjvras/article/view/54037 | - |
dc.identifier.citation | Brazilian Journal of Veterinary Research and Animal Science, v. 49, n. 6, p. 442-451, 2012. | - |
dc.identifier.issn | 1413-9596 | - |
dc.identifier.issn | 1678-4456 | - |
dc.identifier.uri | http://hdl.handle.net/11449/74028 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/74028 | - |
dc.description.abstract | Visceral leishmaniasis in dogs is described as a chronic disease whose main symptoms are progressive weigth loss, cachexy and dermatologic lesions. Recently, the disease has been associated to neurologic disorders. A total of 40 dogs with visceral leishmaniasis were divided into two groups. The first composed of dogs without neurological signs (n=30) and the second by dogs with neurological disorders (n=10). Brain samples were collected, stored in 10% buffered formalin and subjected to immunohistochemical examination for amastigotes forms of Leishmania (Leishmania) infantum chagasi, CD3+, CD4+ and CD8+ T lymphocytes and macrophages. Imunnohistochemistry evaluation revealed no amastigote forms of the parasite. CD3+ T lymphocytes were present in 24/30 (80%) dogs without neurological signs and in all dogs from the second group (p=0.0011). CD4+ and CD8+ were rarely observed, with CD4+ immunostaining in 10/40 (25%) dogs, from which half of them had neurological disease (p=0.0090). The presence of CD8+ was detected only in 4/10 (40%) dogs from neurological group (p=0.0021). Macrophages were detected in 38/40 (95%) dogs, without significant differences between groups (p=0.7664). | en |
dc.format.extent | 442-451 | - |
dc.language.iso | eng | - |
dc.language.iso | por | - |
dc.source | Scopus | - |
dc.subject | Leishmania (Leishmania) infantum chagasi | - |
dc.subject | Macrophages | - |
dc.subject | TCD3+ | - |
dc.subject | TCD4+ | - |
dc.subject | TCD8+ | - |
dc.title | Estudo da imunopatogenia das lesões no sistema nervoso central de cães naturalmente acometidos por leishmaniose visceral | pt |
dc.title.alternative | Study of the immunopathogenesis of central nervous system lesions in dogs naturally affected by visceral leishmaniasis | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.description.affiliation | Universidade Estadual Paulista, Araçatuba-SP | - |
dc.description.affiliation | Departamento de Patologia Universidade de São Paulo, São Paulo-SP | - |
dc.description.affiliation | Universidade Estadual Paulista, Botucatu-SP | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Araçatuba-SP | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Botucatu-SP | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | 2-s2.0-84876498370.pdf | - |
dc.relation.ispartof | Brazilian Journal of Veterinary Research and Animal Science | - |
dc.identifier.scopus | 2-s2.0-84876498370 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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