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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/74151
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dc.contributor.authorLonghini-dos-Santos, Nathalia-
dc.contributor.authorBarbosa-de-Oliveira, Valter Abraão-
dc.contributor.authorKozma, Rodrigo Heras-
dc.contributor.authorde Faria, Carolina Arruda-
dc.contributor.authorStessuk, Talita-
dc.contributor.authorFrei, Fernando-
dc.contributor.authorRibeiro-Paes, João Tadeu-
dc.date.accessioned2014-05-27T11:27:28Z-
dc.date.accessioned2016-10-25T18:40:51Z-
dc.date.available2014-05-27T11:27:28Z-
dc.date.available2016-10-25T18:40:51Z-
dc.date.issued2013-01-01-
dc.identifierhttp://dx.doi.org/10.1007/s12015-012-9419-y-
dc.identifier.citationStem Cell Reviews and Reports, v. 9, n. 2, p. 210-218, 2013.-
dc.identifier.issn1550-8943-
dc.identifier.issn1558-6804-
dc.identifier.urihttp://hdl.handle.net/11449/74151-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/74151-
dc.description.abstractEmphysema is characterized by destruction of alveolar walls with loss of gas exchange surface and consequent progressive dyspnea. This study aimed to evaluate the efficiency of cell therapy with bone marrow mononuclear cells (BMMC) in an animal model of elastase-induced pulmonary emphysema. Emphysema was induced in C57Bl/J6 female mice by intranasal instillation of elastase. After 21 days, the mice received bone marrow mononuclear cells from EGFP male mice with C57Bl/J6 background. The groups were assessed by comparison and statistically significant differences (p & 0. 05) were observed among the groups treated with BMMC and evaluated after 7, 14 and 21 days. Analysis of the mean linear intercept (Lm) values for the different groups allowed to observe that the group treated with BMMC and evaluated after 21 days showed the most significant result. The group that received no treatment showed a statistically significant difference when compared to other groups, except the group treated and evaluated after 21 days, evidencing the efficacy of cell therapy with BMMC in pulmonary emphysema. © 2012 Springer Science+Business Media New York.en
dc.format.extent210-218-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAnimal model-
dc.subjectCell therapy-
dc.subjectCOPD-
dc.subjectPulmonary emphysema-
dc.subjectStem cells-
dc.subjectbiological marker-
dc.subjectpancreatic elastase-
dc.subjectanimal-
dc.subjectbone marrow cell-
dc.subjectbone marrow transplantation-
dc.subjectC57BL mouse-
dc.subjectchemically induced disorder-
dc.subjectchemistry-
dc.subjectcytology-
dc.subjectfemale-
dc.subjecthuman-
dc.subjectimmunology-
dc.subjectimmunophenotyping-
dc.subjectlung-
dc.subjectlung emphysema-
dc.subjectlung lavage-
dc.subjectmale-
dc.subjectmetabolism-
dc.subjectmononuclear cell-
dc.subjectmouse-
dc.subjectpathology-
dc.subjecttransgenic mouse-
dc.subjecttransplantation-
dc.subjectAnimals-
dc.subjectBiological Markers-
dc.subjectBone Marrow Cells-
dc.subjectBone Marrow Transplantation-
dc.subjectBronchoalveolar Lavage Fluid-
dc.subjectFemale-
dc.subjectHumans-
dc.subjectImmunophenotyping-
dc.subjectLeukocytes, Mononuclear-
dc.subjectLung-
dc.subjectMale-
dc.subjectMice-
dc.subjectMice, Inbred C57BL-
dc.subjectMice, Transgenic-
dc.subjectPancreatic Elastase-
dc.subjectPulmonary Emphysema-
dc.subjectAnimalia-
dc.subjectMus-
dc.titleCell Therapy with Bone Marrow Mononuclear Cells in Elastase-Induced Pulmonary Emphysemaen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationInter-units Program of Post-Graduation in Biotechnology University of São Paulo - USP - Butantan Inst. - IPT, São Paulo, SP-
dc.description.affiliationDepartment of Biological Sciences University of the State of São Paulo - UNESP, Assis, SP-
dc.description.affiliationUnespDepartment of Biological Sciences University of the State of São Paulo - UNESP, Assis, SP-
dc.identifier.doi10.1007/s12015-012-9419-y-
dc.identifier.wosWOS:000317074300011-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofStem Cell Reviews and Reports-
dc.identifier.scopus2-s2.0-84875623281-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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