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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/74204
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dc.contributor.authorAguiar, A. F.-
dc.contributor.authorVechetti-Júnior, I. J.-
dc.contributor.authorAlves de Souza, R. W.-
dc.contributor.authorCastan, E. P.-
dc.contributor.authorMilanezi-Aguiar, R. C.-
dc.contributor.authorPadovani, C. R.-
dc.contributor.authorCarvalho, R. F.-
dc.contributor.authorSilva, M. D P-
dc.date.accessioned2014-05-27T11:27:29Z-
dc.date.accessioned2016-10-25T18:41:01Z-
dc.date.available2014-05-27T11:27:29Z-
dc.date.available2016-10-25T18:41:01Z-
dc.date.issued2013-01-01-
dc.identifierhttp://dx.doi.org/10.1055/s-0032-1321895-
dc.identifier.citationInternational Journal of Sports Medicine, v. 34, n. 4, p. 293-301, 2013.-
dc.identifier.issn0172-4622-
dc.identifier.issn1439-3964-
dc.identifier.urihttp://hdl.handle.net/11449/74204-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/74204-
dc.description.abstractThe purpose of this study was to test the hypothesis that skeletal muscle adaptations induced by long-term resistance training (RT) are associated with increased myogenic regulatory factors (MRF) and insulin-like growth factor-I (IGF-I) mRNA expression in rats skeletal muscle. Male Wistar rats were divided into 4 groups: 8-week control (C8), 8-week trained (T8), 12-week control (C12) and 12-week trained (T12). Trained rats were submitted to a progressive RT program (4 sets of 10-12 repetitions at 65-75% of the 1RM, 3 day/week), using a squat-training apparatus with electric stimulation. Muscle hypertrophy was determined by measurement of muscle fiber cross-sectional area (CSA) of the muscle fibers, and myogenin, MyoD and IGF-I mRNA expression were measured by RT-qPCR. A hypertrophic stabilization occurred between 8 and 12 weeks of RT (control-relative % area increase, T8: 29% vs. T12: 35%; p>0.05) and was accompanied by the stabilization of myogenin (control-relative % increase, T8: 44.8% vs. T12: 37.7%, p>0.05) and MyoD (control-relative % increase, T8: 22.9% vs. T12: 22.3%, p>0.05) mRNA expression and the return of IGF-I mRNA levels to the baseline (control-relative % increase, T8: 30.1% vs. T12: 1.5%, p<0.05). Moreover, there were significant positive correlations between the muscle fiber CSA and mRNA expression for MyoD (r=0.85, p=0.0001), myogenin (r=0.87, p=0.0001), and IGF-I (r=0.88, p=0.0001). The significant (p<0.05) increase in myogenin, MyoD and IGF-I mRNA expression after 8 weeks was not associated with changes in the fiber-type frequency. In addition, there was a type IIX/D-to-IIA fiber conversion at 12 weeks, even with the stabilization of MyoD and myogenin expression and the return of IGF-I levels to baseline. These results indicate a possible interaction between MRFs and IGF-I in the control of muscle hypertrophy during long-term RT and suggest that these factors are involved more in the regulation of muscle mass than in fiber-type conversion. © Georg Thieme Verlag KG Stuttgart · New York.en
dc.format.extent293-301-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectfiber-type-
dc.subjectinsulin-like growth factor-
dc.subjectmuscle hypertrophy-
dc.subjectmyogenic regulatory factor-
dc.subjectstrength training-
dc.subjectmessenger RNA-
dc.subjectMyoD protein-
dc.subjectmyogenin-
dc.subjectsomatomedin C-
dc.subjectadaptation-
dc.subjectanimal-
dc.subjectanimal experiment-
dc.subjectgenetics-
dc.subjecthypertrophy-
dc.subjectmale-
dc.subjectmetabolism-
dc.subjectmethodology-
dc.subjectpathology-
dc.subjectrat-
dc.subjectreal time polymerase chain reaction-
dc.subjectskeletal muscle-
dc.subjectWistar rat-
dc.subjectAdaptation, Physiological-
dc.subjectAnimals-
dc.subjectHypertrophy-
dc.subjectInsulin-Like Growth Factor I-
dc.subjectMale-
dc.subjectMuscle Fibers, Skeletal-
dc.subjectMuscle, Skeletal-
dc.subjectMyoD Protein-
dc.subjectMyogenin-
dc.subjectPhysical Conditioning, Animal-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectReal-Time Polymerase Chain Reaction-
dc.subjectRNA, Messenger-
dc.titleMyogenin, MyoD and IGF-I regulate muscle mass but not fiber-type conversion during resistance training in ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationMorphology Univ Estadual Paulista (UNESP), Rubião Júnior District 18618-970 Botucatu-
dc.description.affiliationBioestatística Universidade Estadual Paulista, Botucatu-
dc.description.affiliationInstituto de Biociências de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho Morphology, Botucatu-
dc.description.affiliationUnespMorphology Univ Estadual Paulista (UNESP), Rubião Júnior District 18618-970 Botucatu-
dc.description.affiliationUnespBioestatística Universidade Estadual Paulista, Botucatu-
dc.description.affiliationUnespInstituto de Biociências de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho Morphology, Botucatu-
dc.identifier.doi10.1055/s-0032-1321895-
dc.identifier.wosWOS:000316615100002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInternational Journal of Sports Medicine-
dc.identifier.scopus2-s2.0-84884212061-
dc.identifier.orcid0000-0002-4901-7714pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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