Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/74204
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Aguiar, A. F. | - |
dc.contributor.author | Vechetti-Júnior, I. J. | - |
dc.contributor.author | Alves de Souza, R. W. | - |
dc.contributor.author | Castan, E. P. | - |
dc.contributor.author | Milanezi-Aguiar, R. C. | - |
dc.contributor.author | Padovani, C. R. | - |
dc.contributor.author | Carvalho, R. F. | - |
dc.contributor.author | Silva, M. D P | - |
dc.date.accessioned | 2014-05-27T11:27:29Z | - |
dc.date.accessioned | 2016-10-25T18:41:01Z | - |
dc.date.available | 2014-05-27T11:27:29Z | - |
dc.date.available | 2016-10-25T18:41:01Z | - |
dc.date.issued | 2013-01-01 | - |
dc.identifier | http://dx.doi.org/10.1055/s-0032-1321895 | - |
dc.identifier.citation | International Journal of Sports Medicine, v. 34, n. 4, p. 293-301, 2013. | - |
dc.identifier.issn | 0172-4622 | - |
dc.identifier.issn | 1439-3964 | - |
dc.identifier.uri | http://hdl.handle.net/11449/74204 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/74204 | - |
dc.description.abstract | The purpose of this study was to test the hypothesis that skeletal muscle adaptations induced by long-term resistance training (RT) are associated with increased myogenic regulatory factors (MRF) and insulin-like growth factor-I (IGF-I) mRNA expression in rats skeletal muscle. Male Wistar rats were divided into 4 groups: 8-week control (C8), 8-week trained (T8), 12-week control (C12) and 12-week trained (T12). Trained rats were submitted to a progressive RT program (4 sets of 10-12 repetitions at 65-75% of the 1RM, 3 day/week), using a squat-training apparatus with electric stimulation. Muscle hypertrophy was determined by measurement of muscle fiber cross-sectional area (CSA) of the muscle fibers, and myogenin, MyoD and IGF-I mRNA expression were measured by RT-qPCR. A hypertrophic stabilization occurred between 8 and 12 weeks of RT (control-relative % area increase, T8: 29% vs. T12: 35%; p>0.05) and was accompanied by the stabilization of myogenin (control-relative % increase, T8: 44.8% vs. T12: 37.7%, p>0.05) and MyoD (control-relative % increase, T8: 22.9% vs. T12: 22.3%, p>0.05) mRNA expression and the return of IGF-I mRNA levels to the baseline (control-relative % increase, T8: 30.1% vs. T12: 1.5%, p<0.05). Moreover, there were significant positive correlations between the muscle fiber CSA and mRNA expression for MyoD (r=0.85, p=0.0001), myogenin (r=0.87, p=0.0001), and IGF-I (r=0.88, p=0.0001). The significant (p<0.05) increase in myogenin, MyoD and IGF-I mRNA expression after 8 weeks was not associated with changes in the fiber-type frequency. In addition, there was a type IIX/D-to-IIA fiber conversion at 12 weeks, even with the stabilization of MyoD and myogenin expression and the return of IGF-I levels to baseline. These results indicate a possible interaction between MRFs and IGF-I in the control of muscle hypertrophy during long-term RT and suggest that these factors are involved more in the regulation of muscle mass than in fiber-type conversion. © Georg Thieme Verlag KG Stuttgart · New York. | en |
dc.format.extent | 293-301 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | fiber-type | - |
dc.subject | insulin-like growth factor | - |
dc.subject | muscle hypertrophy | - |
dc.subject | myogenic regulatory factor | - |
dc.subject | strength training | - |
dc.subject | messenger RNA | - |
dc.subject | MyoD protein | - |
dc.subject | myogenin | - |
dc.subject | somatomedin C | - |
dc.subject | adaptation | - |
dc.subject | animal | - |
dc.subject | animal experiment | - |
dc.subject | genetics | - |
dc.subject | hypertrophy | - |
dc.subject | male | - |
dc.subject | metabolism | - |
dc.subject | methodology | - |
dc.subject | pathology | - |
dc.subject | rat | - |
dc.subject | real time polymerase chain reaction | - |
dc.subject | skeletal muscle | - |
dc.subject | Wistar rat | - |
dc.subject | Adaptation, Physiological | - |
dc.subject | Animals | - |
dc.subject | Hypertrophy | - |
dc.subject | Insulin-Like Growth Factor I | - |
dc.subject | Male | - |
dc.subject | Muscle Fibers, Skeletal | - |
dc.subject | Muscle, Skeletal | - |
dc.subject | MyoD Protein | - |
dc.subject | Myogenin | - |
dc.subject | Physical Conditioning, Animal | - |
dc.subject | Rats | - |
dc.subject | Rats, Wistar | - |
dc.subject | Real-Time Polymerase Chain Reaction | - |
dc.subject | RNA, Messenger | - |
dc.title | Myogenin, MyoD and IGF-I regulate muscle mass but not fiber-type conversion during resistance training in rats | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Morphology Univ Estadual Paulista (UNESP), Rubião Júnior District 18618-970 Botucatu | - |
dc.description.affiliation | Bioestatística Universidade Estadual Paulista, Botucatu | - |
dc.description.affiliation | Instituto de Biociências de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho Morphology, Botucatu | - |
dc.description.affiliationUnesp | Morphology Univ Estadual Paulista (UNESP), Rubião Júnior District 18618-970 Botucatu | - |
dc.description.affiliationUnesp | Bioestatística Universidade Estadual Paulista, Botucatu | - |
dc.description.affiliationUnesp | Instituto de Biociências de Botucatu Universidade Estadual Paulista Júlio de Mesquita Filho Morphology, Botucatu | - |
dc.identifier.doi | 10.1055/s-0032-1321895 | - |
dc.identifier.wos | WOS:000316615100002 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | International Journal of Sports Medicine | - |
dc.identifier.scopus | 2-s2.0-84884212061 | - |
dc.identifier.orcid | 0000-0002-4901-7714 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.