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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/74340
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dc.contributor.authorSoares, Grazielle Arantes-
dc.contributor.authorCastro, Ana Doris de-
dc.contributor.authorCury, Beatriz S.F.-
dc.contributor.authorEvangelista, Raul Cesar-
dc.date.accessioned2014-05-27T11:27:33Z-
dc.date.accessioned2016-10-25T18:41:45Z-
dc.date.available2014-05-27T11:27:33Z-
dc.date.available2016-10-25T18:41:45Z-
dc.date.issued2013-01-02-
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2012.08.014-
dc.identifier.citationCarbohydrate Polymers, v. 91, n. 1, p. 135-142, 2013.-
dc.identifier.issn0144-8617-
dc.identifier.urihttp://hdl.handle.net/11449/74340-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/74340-
dc.description.abstractPolymers blends represent an important approach to obtain materials with modulated properties to reach different and desired properties in designing drug delivery systems in order to fulfill therapeutic needs. The aim of this work was to evaluate the influence of drug loading and polymer ratio on the physicochemical properties of microparticles of cross-linked high amylose starch-pectin blends loaded with diclofenac for further application in controlled drug delivery systems. Thermal analysis and X-ray diffractograms evidenced the occurrence of drug-polymer interactions and the former pointed also to an increase in thermal stability due to drug loading. The rheological properties demonstrated that drug loading resulted in formation of weaker gels while the increase of pectin ratio contributes to origin stronger structures. © 2012 Elsevier Ltd.en
dc.format.extent135-142-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectHigh amylose starch-
dc.subjectPectin-
dc.subjectPolymer blends-
dc.subjectRheology-
dc.subjectThermal analysis-
dc.subjectX-ray diffraction-
dc.subjectControlled drug delivery systems-
dc.subjectDiclofenac-
dc.subjectDrug delivery system-
dc.subjectDrug loading-
dc.subjectDrug-polymer interaction-
dc.subjectHigh amylose-
dc.subjectMicro-particles-
dc.subjectPhysicochemical property-
dc.subjectRheological property-
dc.subjectX-ray diffractograms-
dc.subjectControlled drug delivery-
dc.subjectCrosslinking-
dc.subjectFunctional polymers-
dc.subjectMaterials properties-
dc.subjectStarch-
dc.subjectThermoanalysis-
dc.subjectX ray diffraction-
dc.subjectLoading-
dc.subjectamylose-
dc.subjectdiclofenac-
dc.subjectdrug carrier-
dc.subjectmicrosphere-
dc.subjectpectin-
dc.subjectchemistry-
dc.subjectflow kinetics-
dc.subjectparticle size-
dc.subjecttemperature-
dc.subjectAmylose-
dc.subjectDrug Carriers-
dc.subjectMicrospheres-
dc.subjectParticle Size-
dc.subjectPectins-
dc.subjectTemperature-
dc.titleBlends of cross-linked high amylose starch/pectin loaded with diclofenacen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationFaculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos Universidade Estadual Paulista UNESP, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP-
dc.description.affiliationUnespFaculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos Universidade Estadual Paulista UNESP, Rodovia Araraquara-Jaú, km 1, CEP 14801-902, Araraquara, SP-
dc.identifier.doi10.1016/j.carbpol.2012.08.014-
dc.identifier.wosWOS:000310253800017-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84865459434.pdf-
dc.relation.ispartofCarbohydrate Polymers-
dc.identifier.scopus2-s2.0-84865459434-
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