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DC Field | Value | Language |
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dc.contributor.author | Oliveira Alves, Mg | - |
dc.contributor.author | Balducci, I. | - |
dc.contributor.author | Rodarte Carvalho, Y. | - |
dc.contributor.author | Cabral, Lag | - |
dc.contributor.author | Nunes, Fd | - |
dc.contributor.author | Almeida, Jd | - |
dc.date.accessioned | 2014-05-27T11:28:16Z | - |
dc.date.accessioned | 2016-10-25T18:43:05Z | - |
dc.date.available | 2014-05-27T11:28:16Z | - |
dc.date.available | 2016-10-25T18:43:05Z | - |
dc.date.issued | 2013-01-30 | - |
dc.identifier | http://dx.doi.org/10.1111/odi.12068 | - |
dc.identifier.citation | Oral Diseases. | - |
dc.identifier.issn | 1354-523X | - |
dc.identifier.issn | 1601-0825 | - |
dc.identifier.uri | http://hdl.handle.net/11449/74434 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/74434 | - |
dc.description.abstract | Objective: The objective of this study was to compare the expression of proteins p53, MDM2, and SUMO-1 in oral lichen planus (OLP) lesions, epithelial dysplasia, and squamous cell carcinoma. Materials and Methods: The sample consisted of the following five groups of cheek mucosa lesions: normal mucosa (NM), inflammatory fibrous hyperplasia (IFH), lichen planus, epithelial dysplasia, and squamous cell carcinoma. The tissue samples were stained with hematoxylin-eosin and submitted to immunohistochemistry using anti-p53, anti-MDM2, and anti-SUMO-1 antibodies. Results: The results of this study demonstrated similar expression of p53 and MDM2 between OLP, oral epithelial dysplasia and, to a lesser extent, between OLP and oral squamous cell carcinoma (OSCC). However, for SUMO-1 a similar expression was observed in OLP, NM, and IFH. Conclusions: The results demonstrated overexpression of important proteins (p53 and MDM2) related to regulatory mechanisms of apoptosis in OLP, suggesting that there is a favorable environment for malignant transformation. The expression of SUMO-1 in OLP was similar to NM and IFH, suggesting that alterations of this protein occur at later stages of carcinogenesis, because important overexpression occurred in oral epithelial dysplasia and OSCC. © 2013 John Wiley & Sons A/S. | en |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | Carcinoma | - |
dc.subject | Immunohistochemical | - |
dc.subject | Lichen planus | - |
dc.subject | Proto-oncogene proteins c-mdm2 | - |
dc.subject | Squamous cell | - |
dc.subject | SUMO-1 protein | - |
dc.subject | Tumor suppressor protein p53 | - |
dc.title | Evaluation of the expression of p53, MDM2, and SUMO-1 in oral lichen planus | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.identifier.doi | 10.1111/odi.12068 | - |
dc.identifier.wos | WOS:000329224800004 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Oral Diseases | - |
dc.identifier.scopus | 2-s2.0-84872809209 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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