You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSerezani, C. Henrique-
dc.contributor.authorKane, Steve-
dc.contributor.authorMedeiros, Alexandra Ivo de-
dc.contributor.authorCornett, Ashley M.-
dc.contributor.authorKim, Sang-Hoon-
dc.contributor.authorMarques, Mariana Morato-
dc.contributor.authorLee, Sang-Pyo-
dc.contributor.authorLewis, Casey-
dc.contributor.authorBourdonnay, Emilie-
dc.contributor.authorBallinger, Megan N.-
dc.contributor.authorWhite, Eric S.-
dc.contributor.authorPeters-Golden, Marc-
dc.identifier.citationScience Signaling. Washington: Amer Assoc Advancement Science, v. 5, n. 210, p. 10, 2012.-
dc.description.abstractMacrophage ingestion of the yeast Candida albicans requires its recognition by multiple receptors and the activation of diverse signaling programs. Synthesis of the lipid mediator prostaglandin E-2 (PGE(2)) and generation of cyclic adenosine monophosphate (cAMP) also accompany this process. Here, we characterized the mechanisms underlying PGE(2)-mediated inhibition of phagocytosis and filamentous actin (F-actin) polymerization in response to ingestion of C. albicans by alveolar macrophages. PGE(2) suppressed phagocytosis and F-actin formation through the PGE(2) receptors EP2 and EP4, cAMP, and activation of types I and II protein kinase A. Dephosphorylation and activation of the actin depolymerizing factor cofilin-1 were necessary for these inhibitory effects of PGE(2). PGE(2)-dependent activation of cofilin-1 was mediated by the protein phosphatase activity of PTEN (phosphatase and tensin homolog deleted on chromosome 10), with which it directly associated. Because enhanced production of PGE(2) accompanies many immunosuppressed states, the PTEN-dependent pathway described here may contribute to impaired antifungal defenses.en
dc.description.sponsorshipAmerican Lung Association-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherAmer Assoc Advancement Science-
dc.sourceWeb of Science-
dc.titlePTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE(2)-Mediated Inhibition of Phagocytosis of Fungien
dc.contributor.institutionUniversity of Michigan-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionEulji Univ-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionGachon Univ Gil Hosp-
dc.description.affiliationUniv Michigan Hlth Syst, Dept Internal Med, Div Pulm & Crit Care Med, Ann Arbor, MI 48109 USA-
dc.description.affiliationSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, Brazil-
dc.description.affiliationEulji Univ, Sch Med, Dept Internal Med, Div Allergy & Resp Med, Seoul 139711, South Korea-
dc.description.affiliationUniv São Paulo, Inst Biomed Sci 4, Dept Immunol, BR-05508000 São Paulo, Brazil-
dc.description.affiliationGachon Univ Gil Hosp, Div Allergy, Inchon 405760, South Korea-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Biol Sci, BR-14801902 Araraquara, Brazil-
dc.description.sponsorshipIdNIH: HL058897-
dc.description.sponsorshipIdNIH: K99HL103777-
dc.description.sponsorshipIdNIH: HL085083-
dc.description.sponsorshipIdCNPq: 201061/2007-4-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofScience Signaling-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.