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http://acervodigital.unesp.br/handle/11449/74469
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DC Field | Value | Language |
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dc.contributor.author | Figueiredo, Leonardo Elias | - |
dc.contributor.author | Cilli, Eduardo Maffud | - |
dc.contributor.author | Molina, Roberto Augusto Silva | - |
dc.contributor.author | Espreafico, Enilza Maria | - |
dc.contributor.author | Tfouni, Elia | - |
dc.date.accessioned | 2014-05-27T11:28:17Z | - |
dc.date.accessioned | 2016-10-25T18:43:16Z | - |
dc.date.available | 2014-05-27T11:28:17Z | - |
dc.date.available | 2016-10-25T18:43:16Z | - |
dc.date.issued | 2013-02-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.inoche.2012.11.007 | - |
dc.identifier.citation | Inorganic Chemistry Communications, v. 28, p. 60-63. | - |
dc.identifier.issn | 1387-7003 | - |
dc.identifier.uri | http://hdl.handle.net/11449/74469 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/74469 | - |
dc.description.abstract | The syntheses and properties of trans-[Ru(NH3) 4(L)(NO)](BF4)3 (L = isonicotinic acid (inaH) (I) or ina-Tat48-60 (II)) are described. Tat48-60, a cell penetrating peptide fragment of the Tat regulatory protein of the HIV virus, was linked to the ruthenium nitrosyl through inaH. I and II release NO after reduction forming trans-[Ru(NH3)4(L)(H2O)]3 +. The IC50 values against B16-F10 melanoma cells of I and II (21 μmol L- 1 and 23 μmol L- 1, respectively) are close to that of the commercially available cisplatin (33 μmol L- 1) and smaller than similar complexes. The cytotoxicity is assigned to the NO released from I and II. © 2012 Elsevier B.V. | en |
dc.format.extent | 60-63 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | B16-F10 melanoma cells | - |
dc.subject | Cell penetrating peptide | - |
dc.subject | Cytotoxicity | - |
dc.subject | Nitric oxide | - |
dc.subject | Ruthenium | - |
dc.subject | Tat48-60 | - |
dc.title | Synthesis and cytotoxicity of a ruthenium nitrosyl nitric oxide donor with isonicotinic acid and a cell penetrating peptide | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Departamento de Química Faculdade de Filosofia Universidade de São Paulo, Av. dos Bandeirantes, 3900, 14040-901, Ribeirão Preto, SP | - |
dc.description.affiliation | Instituto de Química de Araraquara Universidade Estadual Paulista Júlio de Mesquita Filho, Rua Prof. Francisco Degni, 55, 14800-900, Araraquara, SP | - |
dc.description.affiliation | Departamento de Biologia Celular e Molecular e Bioagentes Patogênicos Faculdade de Medicina de Ribeirão Preto Universidade de São Paulo, Av. dos Bandeirantes, 3900, 14049-900, Ribeirão Preto, SP | - |
dc.description.affiliationUnesp | Instituto de Química de Araraquara Universidade Estadual Paulista Júlio de Mesquita Filho, Rua Prof. Francisco Degni, 55, 14800-900, Araraquara, SP | - |
dc.identifier.doi | 10.1016/j.inoche.2012.11.007 | - |
dc.identifier.wos | WOS:000315251700013 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Inorganic Chemistry Communications | - |
dc.identifier.scopus | 2-s2.0-84871380423 | - |
dc.identifier.orcid | 0000-0002-4767-0904 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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