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- 11-Oxoaerothionin isolated from the marine sponge Aplysina fistularis shows anti-inflammatory activity in LPS-stimulated macrophages
- Universidade Estadual Paulista (UNESP)
- Universidade de São Paulo (USP)
- Universidade Federal do Rio de Janeiro (UFRJ)
- Universidade Federal da Bahia (UFBA)
- Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
- FAPESP: 05/60175-2
- FAPESP: 10/50190-2
- CNPq: 471509/2006-0
- Marine sponges of the order Verongida are a rich source of biologically active bromotyrosine-derived secondary metabolites. However, none of these compounds are known to display anti-inflammatory activity. In the present investigation, we report the anti-inflammatory effects of 11-oxoaerothionin isolated from the Verongida sponge Aplysina fistularis. When RAW264.7 cells and primary macrophages were preincubated with 11-oxoaerothionin and stimulated with LPS (lipopolysaccharide), a concentration-dependent inhibition of iNOS (inducible nitric oxide synthase) protein and NO2- (Nitrite) production were observed. The same effect was observed when proinflammatory cytokines and PGE(2) (Prostaglandin E2) production was evaluated. In summary, we demonstrated that in the presence of LPS, 11-oxoaerothionin suppresses NO2 and iNOS expression as well as inflammatory cytokines and PGE(2).
- Immunopharmacology and Immunotoxicology. London: Informa Healthcare, v. 34, n. 6, p. 919-924, 2012.
- Informa Healthcare
- Prostaglandin E2
- inflammatory cytokines
- nitric oxide
- NF-kappa B and lipopolysaccharide
- Acesso restrito
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