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dc.contributor.authorMedeiros, Alexandra Ivo de-
dc.contributor.authorGandolfi, Renata C.-
dc.contributor.authorSecatto, Adriana-
dc.contributor.authorFalcucci, Romulo M.-
dc.contributor.authorFaccioli, Lucia H.-
dc.contributor.authorHajdu, Eduardo-
dc.contributor.authorPeixinho, Solange-
dc.contributor.authorBerlinck, Roberto G. S.-
dc.identifier.citationImmunopharmacology and Immunotoxicology. London: Informa Healthcare, v. 34, n. 6, p. 919-924, 2012.-
dc.description.abstractMarine sponges of the order Verongida are a rich source of biologically active bromotyrosine-derived secondary metabolites. However, none of these compounds are known to display anti-inflammatory activity. In the present investigation, we report the anti-inflammatory effects of 11-oxoaerothionin isolated from the Verongida sponge Aplysina fistularis. When RAW264.7 cells and primary macrophages were preincubated with 11-oxoaerothionin and stimulated with LPS (lipopolysaccharide), a concentration-dependent inhibition of iNOS (inducible nitric oxide synthase) protein and NO2- (Nitrite) production were observed. The same effect was observed when proinflammatory cytokines and PGE(2) (Prostaglandin E2) production was evaluated. In summary, we demonstrated that in the presence of LPS, 11-oxoaerothionin suppresses NO2 and iNOS expression as well as inflammatory cytokines and PGE(2).en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherInforma Healthcare-
dc.sourceWeb of Science-
dc.subjectProstaglandin E2en
dc.subjectinflammatory cytokinesen
dc.subjectnitric oxideen
dc.subjectNF-kappa B and lipopolysaccharideen
dc.title11-Oxoaerothionin isolated from the marine sponge Aplysina fistularis shows anti-inflammatory activity in LPS-stimulated macrophagesen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.contributor.institutionUniversidade Federal da Bahia (UFBA)-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farm, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Dept Analises Clin Toxicol Bromatol, Fac Ciencias Farm, Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Fed Rio de Janeiro, Museu Nacl, BR-21941 Rio de Janeiro, RJ, Brazil-
dc.description.affiliationUniversidade Federal da Bahia (UFBA), Inst Biol, Salvador, BA, Brazil-
dc.description.affiliationUniv São Paulo, Inst Quim São Carlos, BR-13560970 São Carlos, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farm, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 05/60175-2-
dc.description.sponsorshipIdFAPESP: 10/50190-2-
dc.description.sponsorshipIdCNPq: 471509/2006-0-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofImmunopharmacology and Immunotoxicology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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