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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7458
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dc.contributor.authorSantos, Jean L.-
dc.contributor.authorYamasaki, Paulo R.-
dc.contributor.authorChin, Chung Man-
dc.contributor.authorTakashi, Celio H.-
dc.contributor.authorPavan, Fernando Rogério-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.date.accessioned2014-05-20T13:24:14Z-
dc.date.accessioned2016-10-25T16:44:58Z-
dc.date.available2014-05-20T13:24:14Z-
dc.date.available2016-10-25T16:44:58Z-
dc.date.issued2009-06-01-
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2009.04.042-
dc.identifier.citationBioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 17, n. 11, p. 3795-3799, 2009.-
dc.identifier.issn0968-0896-
dc.identifier.urihttp://hdl.handle.net/11449/7458-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7458-
dc.description.abstractNew phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 mu/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent3795-3799-
dc.language.isoeng-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectPhthalimide derivativesen
dc.subjectAntimycobacterialen
dc.subjectAntitubercular activityen
dc.subjectCytotoxicityen
dc.titleSynthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivativesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 07/54983-4-
dc.description.sponsorshipIdFAPESP: 07/561150-
dc.description.sponsorshipIdFAPESP: 08/10390-2-
dc.identifier.doi10.1016/j.bmc.2009.04.042-
dc.identifier.wosWOS:000266117400007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBioorganic & Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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