You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorPavan, Fernando Rogério-
dc.contributor.authorMaia, Pedro I. da S.-
dc.contributor.authorLeite, Sergio R. A.-
dc.contributor.authorDeflon, Victor M.-
dc.contributor.authorBatista, Alzir A.-
dc.contributor.authorSato, Daisy N.-
dc.contributor.authorFranzblau, Scott G.-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 45, n. 5, p. 1898-1905, 2010.-
dc.description.abstractThe aim of this study was to identify a candidate drug for the development of anti-tuberculosis therapy from previously synthesized compounds based on the thiosemicarbazones, semicarbazones, dithio-carbazates and hydrazide/hydrazones compounds. The minimal inhibitory concentration (MIC) of these compounds against Mycobacterium tuberculosis was determined. Their in vitro cytotoxicity to J774 cells (IC(50)) was determined to establish a selectivity index (SI) (SI = IC(50)/MIC). The best compounds were the thiosemicarbazones (2, 3 and 4) and the hydrazide/hydrazones (14, 15, 16 and 18). The results are comparable to or better than those of "first line" or "second line" drugs commonly used to treat TB, suggesting these compounds as anti-TB drug candidates. (C) 2010 Elsevier Masson SAS. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier-
dc.sourceWeb of Science-
dc.subjectAntimycobacterial agentsen
dc.titleThiosemicarbazones, semicarbazones, dithiocarbazates and hydrazide/hydrazones: Anti-Mycobacterium tuberculosis activity and cytotoxicityen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.contributor.institutionUniv Illinois-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Inst Quim São Carlos, BR-1356659 São Carlos, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13565905 São Carlos, SP, Brazil-
dc.description.affiliationInst Adolfo Lutz Registro, Unidade Ribeirao Preto, BR-14085410 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 08/10390-2-
dc.description.sponsorshipIdFAPESP: 09/06499-1-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.