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Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease
Universidade Estadual Paulista (UNESP)
  • 1465-9921
  • 1465-993X
Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. Trial registration: No.:NCT00605540. © 2013 Ferrari et al; licensee BioMed Central Ltd.
Issue Date: 
Respiratory Research, v. 14, n. 1, 2013.
  • Biomarkers
  • Chronic Obstructive Pulmonary Disease
  • Exercise
  • Inflammation
  • C reactive protein
  • interleukin 6
  • biological marker
  • IL6 protein, human
  • adult
  • body mass
  • chronic obstructive lung disease
  • clinical evaluation
  • controlled study
  • disease association
  • disease duration
  • disease exacerbation
  • enzyme linked immunosorbent assay
  • exercise tolerance
  • female
  • follow up
  • human
  • major clinical study
  • male
  • mortality
  • nutritional status
  • outcome assessment
  • prediction
  • proportional hazards model
  • prospective study
  • protein blood level
  • walking
  • blood
  • Brazil
  • exercise test
  • middle aged
  • prevalence
  • risk factor
  • statistics
  • survival
  • survival rate
  • Biological Markers
  • C-Reactive Protein
  • Exercise Test
  • Exercise Tolerance
  • Female
  • Follow-Up Studies
  • Humans
  • Interleukin-6
  • Male
  • Middle Aged
  • Prevalence
  • Pulmonary Disease, Chronic Obstructive
  • Risk Factors
  • Survival Analysis
  • Survival Rate
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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