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DC Field | Value | Language |
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dc.contributor.author | Ferrari, Renata | - |
dc.contributor.author | Tanni, Suzana E. | - |
dc.contributor.author | Caram, Laura M.O. | - |
dc.contributor.author | Corrêa, Corina | - |
dc.contributor.author | Corrêa, Camila Renata | - |
dc.contributor.author | Godoy, Irma de | - |
dc.date.accessioned | 2014-05-27T11:28:31Z | - |
dc.date.accessioned | 2016-10-25T18:44:45Z | - |
dc.date.available | 2014-05-27T11:28:31Z | - |
dc.date.available | 2016-10-25T18:44:45Z | - |
dc.date.issued | 2013-02-20 | - |
dc.identifier | http://dx.doi.org/10.1186/1465-9921-14-24 | - |
dc.identifier.citation | Respiratory Research, v. 14, n. 1, 2013. | - |
dc.identifier.issn | 1465-9921 | - |
dc.identifier.issn | 1465-993X | - |
dc.identifier.uri | http://hdl.handle.net/11449/74616 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/74616 | - |
dc.description.abstract | Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements [0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality [Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change [5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. Trial registration: No.:NCT00605540. © 2013 Ferrari et al; licensee BioMed Central Ltd. | en |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | Biomarkers | - |
dc.subject | Chronic Obstructive Pulmonary Disease | - |
dc.subject | Exercise | - |
dc.subject | Inflammation | - |
dc.subject | C reactive protein | - |
dc.subject | interleukin 6 | - |
dc.subject | biological marker | - |
dc.subject | IL6 protein, human | - |
dc.subject | adult | - |
dc.subject | body mass | - |
dc.subject | chronic obstructive lung disease | - |
dc.subject | clinical evaluation | - |
dc.subject | controlled study | - |
dc.subject | disease association | - |
dc.subject | disease duration | - |
dc.subject | disease exacerbation | - |
dc.subject | enzyme linked immunosorbent assay | - |
dc.subject | exercise tolerance | - |
dc.subject | female | - |
dc.subject | follow up | - |
dc.subject | human | - |
dc.subject | major clinical study | - |
dc.subject | male | - |
dc.subject | mortality | - |
dc.subject | nutritional status | - |
dc.subject | outcome assessment | - |
dc.subject | prediction | - |
dc.subject | proportional hazards model | - |
dc.subject | prospective study | - |
dc.subject | protein blood level | - |
dc.subject | walking | - |
dc.subject | blood | - |
dc.subject | Brazil | - |
dc.subject | exercise test | - |
dc.subject | middle aged | - |
dc.subject | prevalence | - |
dc.subject | risk factor | - |
dc.subject | statistics | - |
dc.subject | survival | - |
dc.subject | survival rate | - |
dc.subject | Biological Markers | - |
dc.subject | C-Reactive Protein | - |
dc.subject | Exercise Test | - |
dc.subject | Exercise Tolerance | - |
dc.subject | Female | - |
dc.subject | Follow-Up Studies | - |
dc.subject | Humans | - |
dc.subject | Interleukin-6 | - |
dc.subject | Male | - |
dc.subject | Middle Aged | - |
dc.subject | Prevalence | - |
dc.subject | Pulmonary Disease, Chronic Obstructive | - |
dc.subject | Risk Factors | - |
dc.subject | Survival Analysis | - |
dc.subject | Survival Rate | - |
dc.title | Three-year follow-up of Interleukin 6 and C-reactive protein in chronic obstructive pulmonary disease | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Faculdade de Medicina de Botucatu Univ Estadual Paulista, Unesp Disciplina de Pneumologia, Botucatu, São Paulo | - |
dc.description.affiliationUnesp | Faculdade de Medicina de Botucatu Univ Estadual Paulista, Unesp Disciplina de Pneumologia, Botucatu, São Paulo | - |
dc.identifier.doi | 10.1186/1465-9921-14-24 | - |
dc.identifier.wos | WOS:000317734600001 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | 2-s2.0-84873948021.pdf | - |
dc.relation.ispartof | Respiratory Research | - |
dc.identifier.scopus | 2-s2.0-84873948021 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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