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DC Field | Value | Language |
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dc.contributor.author | de Souza, Rodrigo A. | - |
dc.contributor.author | Stevanato, Alessandra | - |
dc.contributor.author | Treu-Filho, Oswaldo | - |
dc.contributor.author | Netto, Adelino Vieira de Godoy | - |
dc.contributor.author | Mauro, Antonio Eduardo | - |
dc.contributor.author | Castellano, Eduardo E. | - |
dc.contributor.author | Carlos, Iracilda Z. | - |
dc.contributor.author | Pavan, Fernando R. | - |
dc.contributor.author | Leite, Clarice Q. F. | - |
dc.date.accessioned | 2014-05-20T13:24:14Z | - |
dc.date.accessioned | 2016-10-25T16:44:58Z | - |
dc.date.available | 2014-05-20T13:24:14Z | - |
dc.date.available | 2016-10-25T16:44:58Z | - |
dc.date.issued | 2010-11-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.ejmech.2010.07.057 | - |
dc.identifier.citation | European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 45, n. 11, p. 4863-4868, 2010. | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7462 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/7462 | - |
dc.description.abstract | Complexes of the type trans-[PdX2(isn)(2)] {X = Cl (1), N-3 (2), SCN (3), NCO (4); isn = isonicotinamide} were synthesized and evaluated for in vitro antimycobacterial and antitumor activities. The coordination mode of the isonicotinamide and the pseudohalide ligands was inferred by IR spectroscopy. Single crystal X-ray diffraction determination on 2 showed that coordination geometry around Pd(II) is nearly square planar, with the ligands in a trans configuration. All the compounds demonstrated better in vitro activity against Mycobacterium tuberculosis than isonicotinamide and pyrazinamide. Among the complexes, compound 2 was found to be the most active with MIC of 35.89 mu M. Complexes 1-4 were also screened for their in vitro antitumor activity towards LM3 and LP07 murine cancer cell lines. (C) 2010 Elsevier Masson SAS. All rights reserved. | en |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 4863-4868 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier France-editions Scientifiques Medicales Elsevier | - |
dc.source | Web of Science | - |
dc.subject | Palladium(II) complexes | en |
dc.subject | Isonicotinamide | en |
dc.subject | Cytotoxicity assays | en |
dc.subject | Antimycobacterial | en |
dc.subject | Antitumor activity | en |
dc.title | Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N-3)(2)(isn)(2)] | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.description.affiliation | UNESP São Paulo State Univ, Inst Quim Araraquara, BR-14800900 Araraquara, SP, Brazil | - |
dc.description.affiliation | Univ São Paulo, Inst Fis São Carlos, BR-13560970 São Carlos, SP, Brazil | - |
dc.description.affiliation | UNESP São Paulo State Univ, Fac Ciencias Farmaceut, BR-14800900 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP São Paulo State Univ, Inst Quim Araraquara, BR-14800900 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP São Paulo State Univ, Fac Ciencias Farmaceut, BR-14800900 Araraquara, SP, Brazil | - |
dc.identifier.doi | 10.1016/j.ejmech.2010.07.057 | - |
dc.identifier.wos | WOS:000283911300020 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | European Journal of Medicinal Chemistry | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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