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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/74630
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dc.contributor.authorSilveira, Jéssica P.S.-
dc.contributor.authorSeito, Leonardo N.-
dc.contributor.authorEberlin, Samara-
dc.contributor.authorDieamant, Gustavo C.-
dc.contributor.authorNogueira, Cecília-
dc.contributor.authorPereda, Maria C.V.-
dc.contributor.authorDi Stasi, Luiz C.-
dc.date.accessioned2014-05-27T11:28:33Z-
dc.date.accessioned2016-10-25T18:44:51Z-
dc.date.available2014-05-27T11:28:33Z-
dc.date.available2016-10-25T18:44:51Z-
dc.date.issued2013-02-27-
dc.identifierhttp://dx.doi.org/10.1186/1472-6882-13-49-
dc.identifier.citationBMC Complementary and Alternative Medicine, v. 13.-
dc.identifier.issn1472-6882-
dc.identifier.urihttp://hdl.handle.net/11449/74630-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/74630-
dc.description.abstractBackground: Exposure to ultraviolet (UV) radiation causes various forms of acute and chronic skin damage, including immunosuppression, inflammation, premature aging and photodamage. Furthermore, it induces the generation of reactive oxygen species, produces proinflammatory cytokines and melanocyte-stimulating hormone (MSH) and increases tyrosinase activity. The aim of this study was to evaluate the potential photoprotective effects of Rheum rhaponticum L. rhizome extract on human UV-stimulated melanocytes.Methods: The effects of Rheum rhaponticum rhizome extract on tyrosine kinase activity, and on interleukin-1α (IL-1α), tumour necrosis factor α (TNF-α), and α-MSH production in human epidermal melanocytes were evaluated under UV-stimulated and non-stimulated conditions. Antioxidant activity was evaluated by lipid peroxidation and 1,1-dyphenyl-2-picryl-hydrazyl (DPPH) assays, while anti-tyrosinase activity was evaluated by the mushroom tyrosinase method.Results: Rheum rhaponticum L. rhizome extract showed in vitro antioxidant properties against lipid peroxidation, free radical scavenging and anti-tyrosinase activities, and inhibited the production of IL-1α, TNF-α, α-MSH, and tyrosine kinase activity in melanocytes subjected to UV radiation.Conclusions: These results support the inclusion of Rheum rhaponticum L. rhizome extract into cosmetic, sunscreen and skin care products for the prevention or reduction of photodamage. © 2013 Silveira et al; licensee BioMed Central Ltd.en
dc.language.isoeng-
dc.sourceScopus-
dc.subjectα-MSH-
dc.subjectMelanocytes-
dc.subjectPhotoprotection-
dc.subjectRheum rhaponticum-
dc.subjectSkin-lightening-
dc.subjectUV radiation-
dc.subject1,1 diphenyl 2 picrylhydrazyl-
dc.subjectalpha intermedin-
dc.subjectinterleukin 1alpha-
dc.subjectlipid-
dc.subjectmonophenol monooxygenase-
dc.subjectprotein tyrosine kinase-
dc.subjectrhubarb extract-
dc.subjecttumor necrosis factor alpha-
dc.subjectantioxidant activity-
dc.subjectcontrolled study-
dc.subjectcytokine production-
dc.subjectdrug effect-
dc.subjectenzyme activity-
dc.subjectenzyme inhibition-
dc.subjecthuman-
dc.subjecthuman cell-
dc.subjectin vitro study-
dc.subjectlipid peroxidation-
dc.subjectmelanocyte-
dc.subjectradiation protection-
dc.subjectrheum rhaponticum-
dc.subjectrhubarb-
dc.subjectskin protection-
dc.subjectultraviolet radiation-
dc.subjectalpha-MSH-
dc.subjectAntioxidants-
dc.subjectBiphenyl Compounds-
dc.subjectCytokines-
dc.subjectEnzyme Inhibitors-
dc.subjectFree Radical Scavengers-
dc.subjectHumans-
dc.subjectInflammation Mediators-
dc.subjectInterleukin-1alpha-
dc.subjectLipid Peroxidation-
dc.subjectMonophenol Monooxygenase-
dc.subjectPhytotherapy-
dc.subjectPicrates-
dc.subjectPlant Extracts-
dc.subjectProtein-Tyrosine Kinases-
dc.subjectRheum-
dc.subjectRhizome-
dc.subjectSkin-
dc.subjectSkin Diseases-
dc.subjectTumor Necrosis Factor-alpha-
dc.subjectUltraviolet Rays-
dc.titlePhotoprotective and antioxidant effects of Rhubarb: Inhibitory action on tyrosinase and tyrosine kinase activities and TNF-α, IL-1α and α-MSH production in human melanocytesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionResearch and Development Department of Chemyunion Chemistry Ltd-
dc.description.affiliationLaboratory of Phytomedicines Department of Pharmacology Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo CEP 18618-970-
dc.description.affiliationResearch and Development Department of Chemyunion Chemistry Ltd, Av Independência 1501, Sorocaba, São Paulo CEP 18087-101-
dc.description.affiliationUnespLaboratory of Phytomedicines Department of Pharmacology Institute of Biosciences, Universidade Estadual Paulista (UNESP), Botucatu, São Paulo CEP 18618-970-
dc.identifier.doi10.1186/1472-6882-13-49-
dc.identifier.wosWOS:000315928300001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84874238639.pdf-
dc.relation.ispartofBMC Complementary and Alternative Medicine-
dc.identifier.scopus2-s2.0-84874238639-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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