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dc.contributor.authordo Nascimento, Fabio B.-
dc.contributor.authorVon Poelhsitz, Gustavo-
dc.contributor.authorPavan, Fernando Rogério-
dc.contributor.authorSato, Daisy N.-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.contributor.authorSelistre-de-Araujo, Heloisa S.-
dc.contributor.authorEllena, Javier-
dc.contributor.authorCastellano, Eduardo E.-
dc.contributor.authorDeflon, Victor M.-
dc.contributor.authorBatista, Alzir A.-
dc.identifier.citationJournal of Inorganic Biochemistry. New York: Elsevier B.V., v. 102, n. 9, p. 1783-1789, 2008.-
dc.description.abstractThe reaction of cis-[RuCl2(dppb)(N-N)], dppb = 1,4-bis(diphenylphosphino)butane, complexes with the ligand HSpymMe(2), 4,6-dimethyl-2-mercaptopyrimidine, yielded the cationic complexes [Ru(SpymMe(2))(dppb)(N-N)]PF6, N-N = bipy (1) and Me-bipy (2), bipy = 2,2'-bipyridine and Me-bipy = 4,4'dimethyl-2,2'-bipyridine, which were characterized by spectroscopic and electrochemical techniques and X-ray crystallography and elemental analysis. Additionally, preliminary in vitro tests for antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27264 and antitumor activity against the MDA-MB-231 human breast tumor cell line were carried out on the new complexes and also on the precursors cis-[RuCl2(dppb)(N-N)], N-N = bipy (3) and Me-bipy (4) and the free ligands dppb, bipy, Me-bipy and SpymMe(2). The minimal inhibitory concentration (MIC) of compounds needed to kill 90% of mycobacterial cells and the IC50 values for the antitumor activity were determined. Compounds 1-4 exhibited good in vitro activity against M. tuberculosis, with MIC values ranging between 0.78 and 6.25 mu g/mL, compared to the free ligands (MIC of 25 to >50 mu g/mL) and the drugs used to treat tuberculosis. Complexes I and 2 also showed promising antitumor activity, with IC50 values of 0.46 +/- 0.02 and 0.43 +/- 0.08 mu M, respectively, against MDA-MB-231 breast tumor cells. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipPrograma de Apoio aos Núcleos de Excelência (PRONEX)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectruthenium (II) complexen
dc.subjectantimycobacterial activityen
dc.titleSynthesis, characterization, X-ray structure and in vitro anti mycobacterial and antitumoral activities of Ru(II) phosphine/diimine complexes containing the "SpymMe(2)" ligand, SpymMe(2)=4,6-dimethyl-2-mercaptopyrimidineen
dc.contributor.institutionUniversidade Federal de Goiás (UFG)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Quim, BR-75704020 Catalao, Go, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13565905 São Carlos, SP, Brazil-
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationInst Adolfo Lutz Registro, Lab Ribeirao Preto, BR-14085410 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Ciencias Fisiol, BR-13565905 São Carlos, SP, Brazil-
dc.description.affiliationUniv São Paulo, Inst Fis, BR-13560970 São Carlos, SP, Brazil-
dc.description.affiliationUniv São Paulo, Inst Quim, BR-13560970 São Carlos, SP, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, BR-14800900 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Inorganic Biochemistry-
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