You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorCuin, Alexandre-
dc.contributor.authorMassabni, Antonio Carlos-
dc.contributor.authorPereira, Guilherme Alves-
dc.contributor.authorFujimura Leite, Clarice Queico-
dc.contributor.authorPavan, Fernando Rogerio-
dc.contributor.authorSesti-Costa, Renata-
dc.contributor.authorHeinrich, Tassiele Andrea-
dc.contributor.authorCosta-Neto, Claudio M.-
dc.identifier.citationBiomedicine & Pharmacotherapy. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 65, n. 5, p. 334-338, 2011.-
dc.description.abstractSynthesis, characterization and biological studies of silver and gold complexes with 6-mercaptopurine (H2MP) are described. The Ag(I) and Au(I) complexes with HMP-, AgHMP and AuIHMP, were obtained by mixing an acidified H2MP aqueous solution with an equimolar aqueous solution of AgNO3 or Au(CN)2. The Au(III) complex with HMP-, AuIIIHMP, was obtained by adding an aqueous solution of K(AuCl4) to an acidified H2MP aqueous solution (1: 1 molar ratio) and the final solution was acidified with HCl to pH = 1.0. The Au(III) MP complex, KAu(MP)2, was obtained by adding an aqueous solution of K(AuCl4) to a basic H2MP solution (M: L - 1: 2 molar ratio). Formulas for the complexes are: (Ag[C5H3N4S])*H2O for AgHMP, (Au[C5H3N4S]) for AuIHMP, (Au[C5H3N4S][Cl]2)*2H2O for AuIIIHMP and K(Au[C5H2N4S]2)center dot 2H2O for KAu(MP) 2. The AuIHMP and KAu(MP) 2 complexes decreased cell viability of HeLa cancer cells in vitro. The IC50 values for AuIHMP and KAu(MP) 2 are 3.0 and 30.0 mu M, respectively. Anti-M. tuberculosis assays showed a MIC value of 2.24 mu M for AuIHMP and 5.12 mu M for free MP while AgHMP is active at the concentration 93.2 mu M. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier-
dc.sourceWeb of Science-
dc.title6-Mercaptopurine complexes with silver and gold ions: Anti-tuberculosis and anti-cancer activitiesen
dc.contributor.institutionUniversidade Federal de Juiz de Fora (UFJF)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUFJF, Inst Ciencias Exatas, Dept Quim, Juiz de Fora, MG, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, São Paulo, Brazil-
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, Araraquara, SP, Brazil-
dc.description.affiliationUSP, Fac Med, Dept Bioquim & Imunol, Ribeirao Preto, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Geral & Inorgan, São Paulo, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Ciencias Biol, Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 06/58923-3-
dc.description.sponsorshipIdFAPESP: 07/55851-4-
dc.description.sponsorshipIdCNPq: 151.528/2004-7-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofBiomedicine & Pharmacotherapy-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.