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dc.contributor.authorPavan, Fernando Rogério-
dc.contributor.authorVon Poelhsitz, Gustavo-
dc.contributor.authordo Nascimento, Fabio B.-
dc.contributor.authorLeite, Sergio R. A.-
dc.contributor.authorBatista, Alzir A.-
dc.contributor.authorDeflon, Victor M.-
dc.contributor.authorSato, Daisy N.-
dc.contributor.authorFranzblau, Scott G.-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 45, n. 2, p. 598-601, 2010.-
dc.description.abstractThe synthesis, characterization and the anti-Mycobacterium tuberculosis (MTB) activities of three ruthenium complexes containing the 2-pyridinecarboxylic acid anion (picolinate), with formulae cis-[Ru(pic)(dppm)(2)]PF(6) (1), Cis- [Ru(pic)(dppe)(2)]PF(6) (2) and [Ru(pic)(2)(PPh(3))(2)] (3) [pic = 2-pyridinecarboxylate; dppm = bis(diphenylphosphino)methane: dppe = 1,2-bis(diphenylphosphino)ethane; PPh(3) = triphenylphosphine] are reported in this article. The complexes were characterized by elemental analysis, spectroscopic and electrochemical techniques. Their in vitro anti mycobacterial activity was determinated as the Minimum Inhibitory Concentration (MIC) for MTB cell growth, measured by the REMA method. The best MICs were found for complexes (1) and (2), with values of 0.78 and 0.26 mu g/mL, respectively. The results are comparable to or better than "first line" or "second line" drugs commonly used in the treatment of TB. (C) 2009 Elsevier Masson SAS. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier-
dc.sourceWeb of Science-
dc.subjectAntimycobacterial agentsen
dc.subjectMycobacterium tuberculosisen
dc.subjectRuthenium (II) Complexesen
dc.titleRuthenium (II) phosphine/picolinate complexes as antimycobacterial agentsen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Goiás (UFG)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.contributor.institutionUniv Illinois-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Quim, BR-75704020 Catalao, Go, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13565905 São Carlos, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Inst Quim São Carlos, BR-13566590 São Carlos, SP, Brazil-
dc.description.affiliationInst Adolfo Lutz Registro, Unidade Ribeirao Preto, BR-14085410 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 08/10390-2-
dc.description.sponsorshipIdFAPESP: 09/06499-1-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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