You are in the accessibility menu

Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGuido, Bruna Candido-
dc.contributor.authorZanatelli, Marianna-
dc.contributor.authorTavares-De-Lima, Wothan-
dc.contributor.authorOliani, Sonia Maria-
dc.contributor.authorDamazo, Amílcar Sabino-
dc.identifier.citationJournal of Inflammation (United Kingdom), v. 10, n. 1, 2013.-
dc.description.abstractBackground: Intestinal ischemia/reperfusion (IR) injury is a serious and triggering event in the development of remote organ dysfunction, from which the lung is the main target. This condition is characterized by intense neutrophil recruitment, increased microvascular permeability. Intestinal IR is also responsible for induction of adult respiratory distress syndrome, the most serious and life-threatening form of acute lung injury. The purpose of this study was to investigate the effect of annexin-A1 protein as an endogenous regulator of the organ remote injury induced by intestinal ischemia/reperfusion. Male C57bl/6 mice were subjected to intestinal ischemia, induced by 45 min occlusion of the superior mesenteric artery, followed by reperfusion. Results: The intestinal ischemia/reperfusion evoked a high intensity lung inflammation as indicated by the number of neutrophils as compared to control group. Treatment with annexin-A1 peptidomimetic Ac2-26, reduced the number of neutrophils in the lung tissue and increased its number in the blood vessels, which suggests a regulatory effect of the peptide Ac2-26 in the neutrophil migration. Moreover, the peptide Ac2-26 treatment was associated with higher levels of plasma IL-10. Conclusion: Our data suggest that the annexin-A1 peptidomimetic Ac2-26 treatment has a regulatory and protective effect in the intestinal ischemia/reperfusion by attenuation of the leukocyte migration to the lung and induction of the anti-inflammatory cytokine IL-10 release into the plasma. The anti-inflammatory action of annexin-A1 and its peptidomimetic described here may serve as a basis for future therapeutic approach in mitigating inflammatory processes due to intestinal ischemia/reperfusion. © 2013 Guido et al.; licensee BioMed Central Ltd.en
dc.subjectInterleukin-10 (IL-10)-
dc.subjectinterleukin 10-
dc.subjectlipocortin 1-
dc.subjecttumor necrosis factor alpha-
dc.subjectanimal cell-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectcontrolled study-
dc.subjectcytokine production-
dc.subjectdown regulation-
dc.subjectintestine ischemia-
dc.subjectleukocyte migration-
dc.subjectlung blood vessel-
dc.subjectlung injury-
dc.subjectlung parenchyma-
dc.subjectprotein blood level-
dc.subjectprotein expression-
dc.subjectprotein function-
dc.subjectprotein secretion-
dc.subjectreperfusion injury-
dc.subjectsuperior mesenteric artery-
dc.titleAnnexin-A1 peptide down-regulates the leukocyte recruitment and up-regulates interleukin-10 release into lung after intestinal ischemia-reperfusion in miceen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)-
dc.description.affiliationDepartment of Biology; Institute of Biosciences Letras e Ciências Exatas (IBILCE) São Paulo State University (UNESP), São José do Rio Preto, SP 15054-000-
dc.description.affiliationDepartment of Pharmacology Institute of Biomedical Sciences (ICB) University of São Paulo (USP), São Paulo, 05508-900-
dc.description.affiliationDepartment of Basic Science in Health Faculty of Medicine (FM) Federal University of Mato Grosso (UFMT), Mato Grosso, MT 78060-900-
dc.description.affiliationUnespDepartment of Biology; Institute of Biosciences Letras e Ciências Exatas (IBILCE) São Paulo State University (UNESP), São José do Rio Preto, SP 15054-000-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofJournal of Inflammation (United Kingdom)-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.