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DC Field | Value | Language |
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dc.contributor.author | Carmo, Arturene M. L. | - |
dc.contributor.author | Silva, Flavia M. C. | - |
dc.contributor.author | Machado, Patricia A. | - |
dc.contributor.author | Fontes, Ana P. S. | - |
dc.contributor.author | Pavan, Fernando Rogério | - |
dc.contributor.author | Leite, Clarice Queico Fujimura | - |
dc.contributor.author | Leite, Sergio R. de A. | - |
dc.contributor.author | Coimbra, Elaine S. | - |
dc.contributor.author | Da Silva, Adilson D. | - |
dc.date.accessioned | 2014-05-20T13:24:16Z | - |
dc.date.accessioned | 2016-10-25T16:45:00Z | - |
dc.date.available | 2014-05-20T13:24:16Z | - |
dc.date.available | 2016-10-25T16:45:00Z | - |
dc.date.issued | 2011-06-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.biopha.2011.01.003 | - |
dc.identifier.citation | Biomedicine & Pharmacotherapy. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 65, n. 3, p. 204-209, 2011. | - |
dc.identifier.issn | 0753-3322 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7484 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/7484 | - |
dc.description.abstract | A series of 4-amino-7-chloroquinoline derivatives were synthesized by the reaction of 4,7-dichloroquinoline with the corresponding diamine and then with propargyl bromide. In addition, platinum(II) complexes were obtained by reacting some of the organic derivatives with K(2)PtCl(4). Several of the synthesized compounds displayed antituberculosis activities. Compound 3 was 47.5 times more active than amphotericin B against Leishmania chagasi (IC(50) = 0.04 mu g/mL). Compounds 5, 6, 7, 9, 10, 11 and 13 presented promising results against Mycobacterium tuberculosis, with MIC values ranging from 12.5 to 15.6 mu g/mL, comparable to the "first and second line'' drugs used to treat tuberculosis. (C) 2011 Elsevier Masson SAS. All rights reserved. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | BIC/UFJF | - |
dc.format.extent | 204-209 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier France-editions Scientifiques Medicales Elsevier | - |
dc.source | Web of Science | - |
dc.subject | 4-aminoquinoline analogues | en |
dc.subject | Platinum(II) complexes | en |
dc.subject | Antileishmanial | en |
dc.subject | Antitubercular | en |
dc.subject | Leishmania | en |
dc.subject | Mycobacterium tuberculosis | en |
dc.title | Synthesis of 4-aminoquinoline analogues and their platinum(II) complexes as new antileishmanial and antitubercular agents | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de Juiz de Fora (UFJF) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Fed Juiz Fora, Dept Quim, ICE, BR-36036900 Juiz de Fora, MG, Brazil | - |
dc.description.affiliation | Univ Fed Juiz Fora, Dept Parasitol Microbiol & Imunol, ICB, BR-36036900 Juiz de Fora, MG, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Inst Quim, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Quim, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 08/10390-2 | - |
dc.description.sponsorshipId | FAPESP: 09/06499-1 | - |
dc.identifier.doi | 10.1016/j.biopha.2011.01.003 | - |
dc.identifier.wos | WOS:000296960200011 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Biomedicine & Pharmacotherapy | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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