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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/7486
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dc.contributor.authorPavan, Fernando Rogério-
dc.contributor.authorPoelhsitz, Gustavo V.-
dc.contributor.authorBarbosa, Marilia I. F.-
dc.contributor.authorLeite, Sergio R. A.-
dc.contributor.authorBatista, Alzir A.-
dc.contributor.authorEllena, Javier-
dc.contributor.authorSato, Leticia S.-
dc.contributor.authorFranzblau, Scott G.-
dc.contributor.authorMoreno, Virtudes-
dc.contributor.authorGambino, Dinorah-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.date.accessioned2014-05-20T13:24:17Z-
dc.date.accessioned2016-10-25T16:45:01Z-
dc.date.available2014-05-20T13:24:17Z-
dc.date.available2016-10-25T16:45:01Z-
dc.date.issued2011-10-01-
dc.identifierhttp://dx.doi.org/10.1016/j.ejmech.2011.08.023-
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 46, n. 10, p. 5099-5107, 2011.-
dc.identifier.issn0223-5234-
dc.identifier.urihttp://hdl.handle.net/11449/7486-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/7486-
dc.description.abstractThis paper describes the synthesis and characterization of four new ruthenium complexes containing 1,4 bis(diphenylphosphino)butane (dppb), 2-pyridinecarboxylic acid anion (pic) and the diimines [(2,2'-bipyridine (bipy), 4,4'-dimethyl-2,2'-bipyridine (Me-bipy), 4,4'-dichloro-2,2'-bipyridine (Cl-bipy) and 1,10-phenanthroline (phen) as ligands, with formulae [Ru(pic)(dppb)(bipy)]PF6 (SCAR01), [Ru(pic)(dppb) (Me-bipy)]PF6 (SCAR02), [Ru(Pic)(dPPb)(Cl-bipy]PF6 (SCAR03) and [Ru(pic)(dppb)(phen)]PF6 (SCAR04). Additionally, the in vitro anti-Mycobacterium tuberculosis (MTB) activity, cytotoxicity and activity against in vitro infection of these complexes and two more complexes, cis-[Ru(pic)(dppe)(2)]PF6(SCAR05) and cis-[RuCl2(dppb)(bipy)] (SCAR06), and their free ligands are described and discussed. All compounds showed excellent MIC against MTB, low cytotoxicity and a selectivity index higher than 10. Also, all compounds showed significant intracellular inhibition and the compound SCAR05 showed a better activity than rifampin and SQ109. This is the first report of activity against in vitro infection of ruthenium compounds. (C) 2011 Elsevier Masson SAS. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCYTED network RIIDFCM-
dc.format.extent5099-5107-
dc.language.isoeng-
dc.publisherElsevier France-editions Scientifiques Medicales Elsevier-
dc.sourceWeb of Science-
dc.subjectMycobacterium tuberculosisen
dc.subjectDrug resistanceen
dc.subjectRutheniumen
dc.subjectPhosphine/diimine/picolinateen
dc.titleRuthenium(II) phosphine/diimine/picolinate complexes: Inorganic compounds as agents against tuberculosisen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Uberlândia (UFU)-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniv Illinois-
dc.contributor.institutionUniv Barcelona-
dc.contributor.institutionUniv Republica-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Federal de Uberlândia (UFU), Inst Quim, BR-38400902 Uberlandia, MG, Brazil-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Quim, BR-13565905 São Carlos, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Inst Fis São Carlos, BR-13560970 São Carlos, SP, Brazil-
dc.description.affiliationUniv Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA-
dc.description.affiliationUniv Barcelona, Dept Quim Inorgan, E-08028 Barcelona, Spain-
dc.description.affiliationUniv Republica, Fac Quim, Catedra Quim Inorgan, Dept Estrella Campos, Montevideo 11800, Uruguay-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 08/10390-2-
dc.description.sponsorshipIdFAPESP: 09/06499-1-
dc.identifier.doi10.1016/j.ejmech.2011.08.023-
dc.identifier.wosWOS:000296041600033-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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