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dc.contributor.authorMoreira, Luciana-
dc.contributor.authorBins, Helena-
dc.contributor.authorToressan, Ricardo-
dc.contributor.authorFerro, Cláudia-
dc.contributor.authorHarttmann, Thiago-
dc.contributor.authorPetribú, Kátia-
dc.contributor.authorJuruena, Mário Francisco-
dc.contributor.authordo Rosário, Maria Conceição-
dc.contributor.authorFerrão, Ygor Arzeno-
dc.identifier.citationJournal of Psychosomatic Research, v. 74, n. 4, p. 313-319, 2013.-
dc.description.abstractObjective: In women with obsessive-compulsive disorder (OCD), symptom severity appears to fluctuate over the course of the menstrual cycle. The objective of this paper was to compare female OCD patients with and without premenstrual worsening of obsessive-compulsive symptoms (OCS), in terms of the clinical characteristics of OCD. Methods: This was a cross-sectional study involving 455 women with OCD, of whom 226 (49.7%) had experienced premenstrual OCS worsening and 229 (50.3%) had not (PMOCS-worse and PMOCS-same groups, respectively). Data were collected with the original and dimensional versions of the Yale-Brown Obsessive-Compulsive Scale, as well as with the Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI). Results: We found significant differences between the PMOCS-same and PMOCS-worse groups, the latter showing a higher frequency of suicidal ideation (P<.001), suicide attempts (P=.027), current use of selective serotonin reuptake inhibitors (P=.022), lifetime use of mood stabilisers (P=.015), and sexual/religious obsessions (P<.001; OR. =1.90), as well as higher scores on the BDI (P<.001) and BAI (P<.001). Conclusion: Underscoring the fact that OCD is a heterogeneous disorder, there appears to be a subgroup of female OCD patients in whom the premenstrual period is associated with a higher frequency of sexual/religious obsessions, depression, anxiety, and suicidality. This might be attributable to hormonal fluctuations. Further studies are warranted in order to investigate this hypothesis by evaluating such patients at different phases of the menstrual cycle, as well as measuring hormonal levels. © 2012 Elsevier Inc.en
dc.subjectLuteal phase-
dc.subjectObsessive-compulsive symptoms-
dc.subjectPremenstrual period-
dc.subjectSymptom dimensions-
dc.subjectmood stabilizer-
dc.subjectserotonin uptake inhibitor-
dc.subjectBeck Depression Inventory-
dc.subjectclinical feature-
dc.subjectcross-sectional study-
dc.subjectdisease severity-
dc.subjectdrug use-
dc.subjectmajor clinical study-
dc.subjectobsessive compulsive disorder-
dc.subjectsexual behavior-
dc.subjectsuicidal ideation-
dc.subjectYale Brown Obsessive Compulsive Scale-
dc.subjectAntidepressive Agents-
dc.subjectCross-Sectional Studies-
dc.subjectMiddle Aged-
dc.subjectObsessive-Compulsive Disorder-
dc.subjectPremenstrual Syndrome-
dc.subjectPsychiatric Status Rating Scales-
dc.subjectSerotonin Uptake Inhibitors-
dc.subjectSeverity of Illness Index-
dc.subjectSuicide, Attempted-
dc.titleAn exploratory dimensional approach to premenstrual manifestation of obsessive-compulsive disorder symptoms: A multicentre studyen
dc.contributor.institutionThe Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders-
dc.contributor.institutionFederal University of Health Sciences of Porto Alegre-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionKing's College London-
dc.contributor.institutionPresident Vargas Hospital for Mothers and Children-
dc.description.affiliationThe Brazilian Research Consortium on Obsessive-Compulsive Spectrum Disorders, São Paulo-
dc.description.affiliationDepartment of Psychiatry Federal University of Health Sciences of Porto Alegre, Porto Alegre-
dc.description.affiliationDepartment of Psychiatry São Paulo State University, Botucatu-
dc.description.affiliationDepartment of Psychiatry Federal University of Pernambuco, Recife-
dc.description.affiliationDepartment of Psychiatry University of São Paulo at Ribeirão Preto, Ribeirão Preto-
dc.description.affiliationDepartment of Psychiatry Federal University of São Paulo, São Paulo-
dc.description.affiliationInstitute of Psychiatry King's College London, London-
dc.description.affiliationPsychiatric Clinic President Vargas Hospital for Mothers and Children, Porto Alegre-
dc.description.affiliationUnespDepartment of Psychiatry São Paulo State University, Botucatu-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Psychosomatic Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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