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dc.contributor.authorDrumond, Betania Paiva-
dc.contributor.authorMondini, Adriano-
dc.contributor.authorSchmidt, Diane J.-
dc.contributor.authorBosch, Irene-
dc.contributor.authorNogueira, Mauricio Lacerda-
dc.identifier.citationArchives of Virology. Wien: Springer Wien, v. 157, n. 11, p. 2061-2073, 2012.-
dc.description.abstractFollowing successive outbreaks of dengue fever caused predominantly by dengue virus (DENV) 2 and 3, DENV-1 is now the primary serotype circulating in Brazil. We sequenced and analyzed Brazilian DENV-1 genomes and found that all isolates belong to genotype V and are subdivided into three lineages, which were introduced during four different events. The first introduction occurred in 1984-85, the second in 1997-99, and the third and fourth occurred from 2004 to 2007. These events were associated with an increase in genetic diversity but not with positive selection. Moreover, a potential new recombinant strain derived from two distinct lineages was detected. We demonstrate that the dynamics of DENV-1 in Brazil is characterized by introduction, movement, local evolution, and lineage replacement. This study strengthens the relevance of genotype surveillance in order to identify, trace, and control virus populations circulating in Brazil and Latin America.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
dc.publisherSpringer Wien-
dc.sourceWeb of Science-
dc.titlePopulation dynamics of DENV-1 genotype V in Brazil is characterized by co-circulation and strain/lineage replacementen
dc.contributor.institutionUniversidade Federal de Juiz de Fora (UFJF)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionTufts Cummings Sch Vet Med-
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)-
dc.description.affiliationUniv Fed Juiz de Fora, Virol Lab, Juiz de Fora, MG, Brazil-
dc.description.affiliationFac Ciencias Farmaceut UNESP, Lab Saúde Publ, São Paulo, Brazil-
dc.description.affiliationTufts Cummings Sch Vet Med, North Grafton, MA 01536 USA-
dc.description.affiliationMIT, Genome Resources Dengue Consortium, Cambridge, MA 02139 USA-
dc.description.affiliationFac Med Sao Jose Rio Preto FAMERP, Lab Pesquisa Virol, São Paulo, Brazil-
dc.description.affiliationUnespFac Ciencias Farmaceut UNESP, Lab Saúde Publ, São Paulo, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchives of Virology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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