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dc.contributor.authorHiguchi, Célio Takashi-
dc.contributor.authorSannomiya, M.-
dc.contributor.authorPavan, Fernando Rogério-
dc.contributor.authorLeite, S. R. A.-
dc.contributor.authorSato, D. N.-
dc.contributor.authorFranzblau, S. G.-
dc.contributor.authorSacramento, Luis Vitor Silva do-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.identifier.citationEvidence-based Complementary and Alternative Medicine. New York: Hindawi Publishing Corporation, p. 5, 2011.-
dc.description.abstractBioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 mu g mL(-1)), triterpenoids as bassic acid (MIC = 2.5 mu g mL(-1)), alpha-amyrin acetate (MIC = 62.5 mu g mL(-1)), a mixture of lupeol, alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)) and a mixture of lupeol, and acetates of alpha- and beta-amyrin (MIC = 31.5 mu g mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherHindawi Publishing Corporation-
dc.sourceWeb of Science-
dc.titleByrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activityen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInst Adolfo-
dc.contributor.institutionUniv Illinois-
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Unesp, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Unesp, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.affiliationInst Adolfo, Lab Micobacteriol, BR-14085410 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Illinois, Coll Pharm, Inst TB Res, Chicago, IL USA-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Unesp, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Unesp, Inst Quim, BR-14800900 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 02/05503-6-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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