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dc.contributor.authorRocha, Otavio P.-
dc.contributor.authorDe Felicio, Rafael-
dc.contributor.authorRodrigues, Ana Helena B.-
dc.contributor.authorAmbrosio, Daniela L.-
dc.contributor.authorCicarelli, Regina Maria Barretto-
dc.contributor.authorDe Albuquerque, Sergio-
dc.contributor.authorYoung, Maria Claudia M.-
dc.contributor.authorYokoya, Nair S.-
dc.contributor.authorDebonsi, Hosana M.-
dc.identifier.citationMolecules. Basel: Mdpi Ag, v. 16, n. 8, p. 7105-7114, 2011.-
dc.description.abstractThe present study reports the Gas Chromatography-Mass Spectrometry (GC-MS) evaluation of the hexanes and dichloromethane fractions from extracts of the red alga Centroceras clavulatum (C. Agardh) Montagne. Twenty three compounds were identified, totaling ca. 42% of both fractions (0.18 g mass extract). The main constituents of the fractions were hexadecanoic acid (17.6%) and pentadecanoic acid (15.9%). Several secondary metabolites with interesting biological activity, such as (-)-loliolide, neophytadiene, phytol were identified. In addition, several classes of secondary metabolites, including phenolic compounds (e.g., phenylacetic acid), terpene derivatives, fatty acids, halogenated compound (e.g., 2-chlorocyclohexenol), lignoids, steroids, esters, amides (e.g., hexadecanamide), ketones, carboxylic acids, aldehydes and alcohols were observed. The occurrence of several of these structural classes is described for the first time in this species. The same fractions analyzed by GC-MS, and a separate set of polar fractions, were evaluated against two life cycle stages (epimastigote and trypomastigote forms) of the protozoan Trypanosoma cruzi and against phytopatogenic fungi Cladosporium cladosporiodes and C. sphaerospermum. The dichloromethane fraction was active against both T. cruzi forms (epimastigote IC(50) = 19.1 mu g.mL(-1) and trypomastigote IC(50) = 76.2 mu g.mL(-1)). The hexanes and ethyl acetate fractions also displayed activity against both fungi species (200 mu g) by TLC-bioautography.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherMdpi Ag-
dc.sourceWeb of Science-
dc.subjectCentroceras clavulatumen
dc.subjectGC-MS analysisen
dc.subjecttrypanocidal activityen
dc.subjectantifungal activityen
dc.titleChemical Profile and Biological Potential of Non-Polar Fractions from Centroceras clavulatum (C. Agardh) Montagne (Ceramiales, Rhodophyta)en
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionInst Bot-
dc.description.affiliationFac Ciencias Farmaceut Ribeirao Preto USP, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil-
dc.description.affiliationDept Ciencias Biol UNESP, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationFac Ciencias Farmaceut Ribeirao Preto USP, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil-
dc.description.affiliationInst Bot, Nucleo Pesquisas Fisiol & Bioquim Vegetal, BR-04301012 São Paulo, Brazil-
dc.description.affiliationInst Bot, Nucleo Pesquisas Ficol, BR-04301012 São Paulo, Brazil-
dc.description.affiliationUnespDept Ciencias Biol UNESP, Fac Ciencias Farmaceut Araraquara, BR-14801902 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso aberto-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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