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DC Field | Value | Language |
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dc.contributor.author | Resende, Flavia Aparecida | - |
dc.contributor.author | Munari, Carla Carolina | - |
dc.contributor.author | Bentes Monteiro Neto, Moacir de Azevedo | - |
dc.contributor.author | Tavares, Denise Crispim | - |
dc.contributor.author | Bastos, Jairo Kenupp | - |
dc.contributor.author | da Silva Filho, Ademar Alves | - |
dc.contributor.author | Varanda, Eliana Aparecida | - |
dc.date.accessioned | 2014-05-20T13:24:19Z | - |
dc.date.available | 2014-05-20T13:24:19Z | - |
dc.date.issued | 2012-03-01 | - |
dc.identifier | http://dx.doi.org/10.3390/molecules17032335 | - |
dc.identifier.citation | Molecules. Basel: Mdpi Ag, v. 17, n. 3, p. 2335-2350, 2012. | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7503 | - |
dc.description.abstract | Baccharis dracunculifolia is a plant native from Brazil, commonly known as 'Alecrim-do-campo' and 'Vassoura' and used in alternative medicine for the treatment of inflammation, hepatic disorders and stomach ulcers. Previous studies reported that artepillin C (ArtC, 3-{4-hydroxy-3,5-di(3-methyl-2-butenyl)phenyl}-2(E)-propenoic acid), is the main compound of interest in the leaves. This study was undertaken to assess the mutagenic effect of the ethyl acetate extract of B. dracunculifolia leaves (Bd-EAE: 11.4-182.8 mu g/plate) and ArtC (0.69-10.99 mu g/plate) by the Ames test using Salmonella typhimurium strains TA98, TA97a, TA100 and TA102, and to compare the protective effects of Bd-EAE and ArtC against the mutagenicity of a variety of direct and indirect acting mutagens such as 4-nitro-O-phenylenediamine, sodium azide, mitomycin C, benzo[a]pyrene, aflatoxin B1, 2-aminoanthracene and 2-aminofluorene. The mutagenicity test showed that Bd-EAE and ArtC did not induce an increase in the number of revertant colonies indicating absence of mutagenic activity. ArtC showed a similar antimutagenic effect to that of Bd-EAE in some strains of S. typhimurium, demonstrating that the antimutagenic activity of Bd-EAE can be partially attributed to ArtC. The present results showed that the protective effect of whole plant extracts is due to the combined and synergistic effects of a complex mixture of phytochemicals, the total activity of which may result in health benefits. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.format.extent | 2335-2350 | - |
dc.language.iso | eng | - |
dc.publisher | Mdpi Ag | - |
dc.source | Web of Science | - |
dc.subject | Baccharis dracunculifolia | en |
dc.subject | artepillin C | en |
dc.subject | Ames test | en |
dc.subject | antimutagenicity | en |
dc.subject | mutagenicity | en |
dc.title | Comparative Studies of the (Anti) Mutagenicity of Baccharis dracunculifolia and Artepillin C by the Bacterial Reverse Mutation Test | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Franca | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Federal de Juiz de Fora (UFJF) | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Ciencias Biol, BR-14801902 São Paulo, Brazil | - |
dc.description.affiliation | Univ Franca, BR-14404600 São Paulo, Brazil | - |
dc.description.affiliation | Univ São Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil | - |
dc.description.affiliation | Univ Fed Juiz de Fora, Fac Farm, Dept Ciencias Farmaceut, BR-36035900 Juiz de Fora, MG, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Farmaceut Araraquara, Dept Ciencias Biol, BR-14801902 São Paulo, Brazil | - |
dc.identifier.doi | 10.3390/molecules17032335 | - |
dc.identifier.wos | WOS:000302120600006 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | WOS000302120600006.pdf | - |
dc.relation.ispartof | Molecules | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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