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dc.contributor.authorEsteves-Pedro, Natalia Mencacci-
dc.contributor.authorBorim, Thaisa-
dc.contributor.authorNazato, Virginia Sbrugnera-
dc.contributor.authorSilva, Magali Glauzer-
dc.contributor.authorLopes, Patricia Santos-
dc.contributor.authordos Santos, Marcio Galdino-
dc.contributor.authorDal Belo, Chariston Andre-
dc.contributor.authorPrimila Cardoso, Cassia Regina-
dc.contributor.authorVaranda, Eliana Aparecida-
dc.contributor.authorGroppo, Francisco Carlos-
dc.contributor.authorGerenutti, Marli-
dc.contributor.authorOshima-Franco, Yoko-
dc.identifier.citationBmc Complementary and Alternative Medicine. London: Biomed Central Ltd., v. 12, p. 9, 2012.-
dc.description.abstractBackground: Dipteryx alata Vogel popularly known as baru is an important commercial leguminous tree species from the Brazilian Cerrado, which possess medicinal properties, besides its fruits consumption by animals and humans. The use of the naturally occurring plants as herbal remedies and foods mainly from leaves, seeds, flowers and roots of plants or extracts require precautions before ensuring these are safe and efficacious. The objective of this study was to evaluate the safety of D. alata barks extract.Methods: Vegetal drugs of D. alata barks were submitted to quality control assays and further to the safety assays under 1) in vitro parameter by Salmonella (Ames) mutagenicity, and 2) in vivo parameter on the pregnancy of rats.Results: The extract was non-mutagenic to any of the assessed strains TA97a, TA98, TA100 and TA102 even after metabolic activation (+S9). All in vivo parameters (reproductive ability evaluation, physical development of rat offsprings, and neurobehavioral development assays) showed no changes related to control group.Conclusion: D. alata barks extract is neither mutagenic by the Ames test nor toxic in the pregnancy of rats, with no physical-neurobehavioral consequences on the rat offsprings development.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.publisherBiomed Central Ltd.-
dc.sourceWeb of Science-
dc.titleIn vitro and in vivo safety evaluation of Dipteryx alata Vogel extracten
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de Sorocaba (UNISO)-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Federal do Tocantins (UFT)-
dc.contributor.institutionUniversidade Federal do Pampa (UNIPAMPA)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationUNESP São Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 São Paulo, Brazil-
dc.description.affiliationUniv Sorocaba, Sch Pharm, UNISO, BR-18023000 Sorocaba, SP, Brazil-
dc.description.affiliationUniv Fed São Paulo, UNIFESP, BR-09972270 Diadema, SP, Brazil-
dc.description.affiliationFed Univ Tocantins, Postgrad Course Environm Sci, PGCiamb, UFT, BR-77001090 Tocantins, Brazil-
dc.description.affiliationFed Univ Pampa, UNIPAMPA, BR-97300000 Sao Gabriel, RS, Brazil-
dc.description.affiliationState Univ Campinas UNICAMP, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP, Brazil-
dc.description.affiliationUnespUNESP São Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 São Paulo, Brazil-
dc.description.sponsorshipIdFAPESP: 07/53883-6-
dc.description.sponsorshipIdFAPESP: 07/51414-5-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofBMC Complementary and Alternative Medicine-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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