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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75071
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dc.contributor.authorNagata, Maria J.H.-
dc.contributor.authorSantinoni, Carolina S.-
dc.contributor.authorPola, Natália M.-
dc.contributor.authorDe Campos, Natália-
dc.contributor.authorMessora, Michel R.-
dc.contributor.authorBomfim, Suely R.M.-
dc.contributor.authorErvolino, Edilson-
dc.contributor.authorFucini, Stephen E.-
dc.contributor.authorFaleiros, Paula L.-
dc.contributor.authorGarcia, Valdir Gouveia-
dc.contributor.authorBosco, Álvaro Francisco-
dc.date.accessioned2014-05-27T11:28:53Z-
dc.date.accessioned2016-10-25T18:46:54Z-
dc.date.available2014-05-27T11:28:53Z-
dc.date.available2016-10-25T18:46:54Z-
dc.date.issued2013-04-05-
dc.identifierhttp://dx.doi.org/10.1016/j.jphotobiol.2013.01.013-
dc.identifier.citationJournal of Photochemistry and Photobiology B: Biology, v. 121, p. 6-14.-
dc.identifier.issn1011-1344-
dc.identifier.issn1873-2682-
dc.identifier.urihttp://hdl.handle.net/11449/75071-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75071-
dc.description.abstractThis study evaluated the influence of bone marrow aspirate (BMA), low-level laser therapy (LLLT) and their combination on bone healing in surgically created critical-size defects (CSDs) in rat calvaria. 40 rats were divided into four groups: C (control), BMA, LLLT and BMA/LLLT. A 5 mm diameter CSD was created in the calvarium of each animal. In Group C, the defect was filled by blood clot only. In Group BMA, the defect was filled with BMA. In groups LLLT and BMA/LLLT, the defect received laser irradiation (InGaAlP laser), was filled with blood clot or BMA respectively, and irradiated again. Animals were euthanized 30 days postoperatively. Histomorphometric and immunohistochemical analyses were performed. Newly formed bone area (NFBA) was calculated as percentage of the total area of the original defect. Proliferating cell nuclear antigen (PCNA), runt-related transcription factor 2 (Runx2) and osteocalcin (OCN) immunohistochemical staining were performed. PCNA-positive, Runx2-positive and OCN-positive cells were quantified. Data were statistically analyzed. Group BMA/LLLT had significantly greater NFBA than groups C, BMA or LLLT. Group BMA presented significantly greater NFBA than control, while group LLLT did not. Group BMA/LLLT presented a significantly higher number of PCNA-positive and OCN-positive cells than any of the other groups. Groups BMA/LLLT and BMA showed a significantly lower number of Runx2-positive cells than groups C or LLLT. The combination of BMA/LLLT yielded significantly greater bone formation in surgically created CSD in rat calvaria when compared to control, or either treatment alone. © 2013 Elsevier B.V. All rights reserved.en
dc.format.extent6-14-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAnimal model-
dc.subjectBone marrow-
dc.subjectBone regeneration-
dc.subjectImmunohistochemistry-
dc.subjectLow-level laser therapy-
dc.subjectRats-
dc.subjectcycline-
dc.subjectosteocalcin-
dc.subjecttranscription factor RUNX2-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectblood clot-
dc.subjectbone marrow biopsy-
dc.subjectcalvaria-
dc.subjectcontrolled study-
dc.subjectfracture healing-
dc.subjectimmunohistochemistry-
dc.subjectlaser-
dc.subjectlow level laser therapy-
dc.subjectmale-
dc.subjectmorphometrics-
dc.subjectnonhuman-
dc.subjectossification-
dc.subjectpostoperative period-
dc.subjectpriority journal-
dc.subjectrat-
dc.subjectAnimalia-
dc.subjectRattus-
dc.titleBone marrow aspirate combined with low-level laser therapy: A new therapeutic approach to enhance bone healingen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationDepartment of Surgery and Integrated Clinic Dental School of Araçatuba Univ. Estadual Paulista-UNESP-
dc.description.affiliationDepartment of Bucco-Maxillo-Facial Surgery, Traumatology and Periodontology School of Dentistry of Ribeirão Preto University of São Paulo-USP-
dc.description.affiliationDepartment of Clinical, Surgery and Animal Reproduction Veterinary School of Araçatuba Univ. Estadual Paulista-UNESP-
dc.description.affiliationDepartment of Basic Sciences Dental School of Araçatuba Univ. Estadual Paulista-UNESP-
dc.description.affiliationUnespDepartment of Surgery and Integrated Clinic Dental School of Araçatuba Univ. Estadual Paulista-UNESP-
dc.description.affiliationUnespDepartment of Clinical, Surgery and Animal Reproduction Veterinary School of Araçatuba Univ. Estadual Paulista-UNESP-
dc.description.affiliationUnespDepartment of Basic Sciences Dental School of Araçatuba Univ. Estadual Paulista-UNESP-
dc.identifier.doi10.1016/j.jphotobiol.2013.01.013-
dc.identifier.wosWOS:000317944100002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Photochemistry and Photobiology B: Biology-
dc.identifier.scopus2-s2.0-84874637616-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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