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dc.contributor.authorOliveira Junior, Silvio A.-
dc.contributor.authorPadovani, Carlos Roberto-
dc.contributor.authorRodrigues, Sergio A.-
dc.contributor.authorSilva, Nilza R.-
dc.contributor.authorMartinez, Paula F.-
dc.contributor.authorCampos, Dijon HS-
dc.contributor.authorOkoshi, Marina Politi-
dc.contributor.authorOkoshi, Katashi-
dc.contributor.authorDal-Pai, Maeli-
dc.contributor.authorCicogna, Antonio Carlos-
dc.date.accessioned2014-05-27T11:28:55Z-
dc.date.accessioned2016-10-25T18:47:25Z-
dc.date.available2014-05-27T11:28:55Z-
dc.date.available2016-10-25T18:47:25Z-
dc.date.issued2013-04-15-
dc.identifierhttp://dx.doi.org/10.1186/1475-2840-12-65-
dc.identifier.citationCardiovascular Diabetology, v. 12, n. 1, 2013.-
dc.identifier.issn1475-2840-
dc.identifier.urihttp://hdl.handle.net/11449/75117-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75117-
dc.description.abstractBackground: Although hypercaloric interventions are associated with nutritional, endocrine, metabolic, and cardiovascular disorders in obesity experiments, a rational distinction between the effects of excess adiposity and the individual roles of dietary macronutrients in relation to these disturbances has not previously been studied. This investigation analyzed the correlation between ingested macronutrients (including sucrose and saturated and unsaturated fatty acids) plus body adiposity and metabolic, hormonal, and cardiovascular effects in rats with diet-induced obesity. Methods: Normotensive Wistar-Kyoto rats were submitted to Control (CD; 3.2 Kcal/g) and Hypercaloric (HD; 4.6 Kcal/g) diets for 20 weeks followed by nutritional evaluation involving body weight and adiposity measurement. Metabolic and hormonal parameters included glycemia, insulin, insulin resistance, and leptin. Cardiovascular analysis included systolic blood pressure profile, echocardiography, morphometric study of myocardial morphology, and myosin heavy chain (MHC) protein expression. Canonical correlation analysis was used to evaluate the relationships between dietary macronutrients plus adiposity and metabolic, hormonal, and cardiovascular parameters. Results: Although final group body weights did not differ, HD presented higher adiposity than CD. Diet induced hyperglycemia while insulin and leptin levels remained unchanged. In a cardiovascular context, systolic blood pressure increased with time only in HD. Additionally, in vivo echocardiography revealed cardiac hypertrophy and improved systolic performance in HD compared to CD; and while cardiomyocyte size was unchanged by diet, nuclear volume and collagen interstitial fraction both increased in HD. Also HD exhibited higher relative β-MHC content and β/α-MHC ratio than their Control counterparts. Importantly, body adiposity was weakly associated with cardiovascular effects, as saturated fatty acid intake was directly associated with most cardiac remodeling measurements while unsaturated lipid consumption was inversely correlated with these effects. Conclusion: Hypercaloric diet was associated with glycemic metabolism and systolic blood pressure disorders and cardiac remodeling. These effects directly and inversely correlated with saturated and unsaturated lipid consumption, respectively. © 2013 Oliveira Junior et al.; licensee BioMed Central Ltd.en
dc.language.isoeng-
dc.sourceScopus-
dc.subjectCardiac remodeling-
dc.subjectHypercaloric diet-
dc.subjectLipids-
dc.subjectglucose-
dc.subjectinsulin-
dc.subjectleptin-
dc.subjectmyosin heavy chain-
dc.subjectsaturated fatty acid-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectbody weight-
dc.subjectcardiovascular system-
dc.subjectcontrolled study-
dc.subjectechocardiography-
dc.subjectglucose blood level-
dc.subjectinsulin resistance-
dc.subjectlipid diet-
dc.subjectmacronutrient-
dc.subjectmale-
dc.subjectmetabolism-
dc.subjectmorphometrics-
dc.subjectnonhuman-
dc.subjectobesity-
dc.subjectprotein expression-
dc.subjectrat-
dc.subjectsystolic blood pressure-
dc.titleExtensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: A canonical analysisen
dc.typeoutro-
dc.contributor.institutionFederal University of Mato Grosso do Sul-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSchool of Physical Therapy Federal University of Mato Grosso do Sul, Campo Grande, MS-
dc.description.affiliationBotucatu Medical School São Paulo State University, Botucatu, SP-
dc.description.affiliationBotucatu Biosciences Institute São Paulo State University, Botucatu, SP-
dc.description.affiliationUnespBotucatu Medical School São Paulo State University, Botucatu, SP-
dc.description.affiliationUnespBotucatu Biosciences Institute São Paulo State University, Botucatu, SP-
dc.identifier.doi10.1186/1475-2840-12-65-
dc.identifier.wosWOS:000320130800001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84878907471.pdf-
dc.relation.ispartofCardiovascular Diabetology-
dc.identifier.scopus2-s2.0-84878907471-
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