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Acute aerocystitis in Piaractus mesopotamicus: Participation of eicosanoids and pro-inflammatory cytokines
Universidade Estadual Paulista (UNESP)
  • 1050-4648
  • 1095-9947
A total of 360 pacus (Piaractus mesopotamicus) were used to study vascular permeability (VP) and inflammatory cell component (CC) in induced aerocystitis in P. mesopotamicus through inoculation of inactivated Aeromonas hydrophila, and the effect of steroidal and nonsteroidal anti-inflammatory drugs. It was observed that after inoculation of A. hydrophila, the maximum VP occurred 180 min post-stimulus (MPS). Pretreatment with anti-inflammatory drugs inhibited VP, and the inhibitory effect of dexamethasone was seen earlier than the effects caused by meloxicam and indomethacin. Inoculation of the bacterium caused a gradual increase in the accumulation of cells, which reached a maximum 24 h post-stimulus (HPS). Pretreatment with dexamethasone, indomethacin and meloxicam reduced the accumulation of lymphocytes, thrombocytes, granulocytes and macrophages. There was no significant difference between the different doses of the drugs tested. The results suggest that eicosanoids and pro-inflammatory cytokines participate in chemical mediation in acute inflammation in pacus. © 2013 Elsevier Ltd.
Issue Date: 
Fish and Shellfish Immunology, v. 34, n. 5, p. 1057-1062, 2013.
Time Duration: 
  • Chemical mediators
  • Evans blue
  • Inflammation
  • Teleost
  • Vascular alteration
  • antiinflammatory agent
  • bacterial vaccine
  • cytokine
  • dexamethasone
  • icosanoid
  • inactivated vaccine
  • indometacin
  • meloxicam
  • thiazine derivative
  • thiazole derivative
  • Aeromonas hydrophila
  • animal
  • animal disease
  • capillary permeability
  • cell structure
  • Characidae
  • dose response
  • Gram negative infection
  • immunology
  • metabolism
  • microbiology
  • time
  • Animals
  • Anti-Inflammatory Agents
  • Bacterial Vaccines
  • Capillary Permeability
  • Cellular Structures
  • Cytokines
  • Dexamethasone
  • Dose-Response Relationship, Drug
  • Eicosanoids
  • Gram-Negative Bacterial Infections
  • Indomethacin
  • Thiazines
  • Thiazoles
  • Time Factors
  • Vaccines, Inactivated
  • Bacteria (microorganisms)
  • Piaractus mesopotamicus
  • Teleostei
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Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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