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- A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests
- Universidade de São Paulo (USP)
- Universidade Federal de Alfenas (UNIFAL)
- Instituto Adolfo Lutz (IAL)
- Universidade Estadual Paulista (UNESP)
- A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasei, although it had a high level of mutagenicity, as observed in mutagenic activity tests. (c) 2006 Elsevier Masson SAS. All rights reserved.
- European Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 41, n. 10, p. 1196-1200, 2006.
- Elsevier B.V.
- nitrotienyl derivative
- potential antimycobacterial agent
- x-ray structure determination
- antimycobacterial activity
- Acesso restrito
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