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dc.contributor.authorRando, D. G.-
dc.contributor.authorDoriguetto, A. C.-
dc.contributor.authorde Paula da Silva, C. H. Tomich-
dc.contributor.authorEllena, J.-
dc.contributor.authorSato, D. N.-
dc.contributor.authorLeite, Clarice Queico Fujimura-
dc.contributor.authorVaranda, Eliana Aparecida-
dc.contributor.authorFerreira, E. I.-
dc.identifier.citationEuropean Journal of Medicinal Chemistry. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 41, n. 10, p. 1196-1200, 2006.-
dc.description.abstractA duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasei, although it had a high level of mutagenicity, as observed in mutagenic activity tests. (c) 2006 Elsevier Masson SAS. All rights reserved.en
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectnitrotienyl derivativept
dc.subjectpotential antimycobacterial agentpt
dc.subjectx-ray structure determinationpt
dc.subjectantimycobacterial activitypt
dc.titleA duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity testsen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)-
dc.contributor.institutionInstituto Adolfo Lutz (IAL)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, BR-05508900 São Paulo, Brazil-
dc.description.affiliationUniv Fed Alfenas, UNIFALMG, BR-37130903 Alfenas, MG, Brazil-
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, BR-14040903 Ribeirao Preto, Brazil-
dc.description.affiliationUniv São Paulo, Inst Fis Sao Carlos, FFI, Grp Cristalografia, BR-13560970 Sao Carlos, SP, Brazil-
dc.description.affiliationInst Adolfo Lutz Registro, BR-14085410 Ribeirao Preto, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, BR-14801902 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Medicinal Chemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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