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dc.contributor.authorRocha, Bruno Alves-
dc.contributor.authorBueno, Paula Carolina Pires-
dc.contributor.authorVaz, Mirela Mara de Oliveira Lima Leite-
dc.contributor.authorNascimento, Andresa Piacezzi-
dc.contributor.authorFerreira, Nathália Ursoli-
dc.contributor.authorMoreno, Gabriela de Padua-
dc.contributor.authorRodrigues, Marina Rezende-
dc.contributor.authorCosta-Machado, Ana Rita de Mello-
dc.contributor.authorBarizon, Edna Aparecida-
dc.contributor.authorCampos, Jacqueline Costa Lima-
dc.contributor.authorDe Oliveira, Pollyanna Francielli-
dc.contributor.authorAcésio, Nathália de Oliveira-
dc.contributor.authorMartins, Sabrina de Paula Lima-
dc.contributor.authorTavares, Denise Crispim-
dc.contributor.authorBerretta, Andresa Aparecida-
dc.identifier.citationEvidence-based Complementary and Alternative Medicine, v. 2013.-
dc.description.abstractSince the beginning of propolis research, several groups have studied its antibacterial, antifungal, and antiviral properties. However, most of these studies have only employed propolis ethanolic extract (PEE) leading to little knowledge about the biological activities of propolis water extract (PWE). Based on this, in a previous study, we demonstrated the anti-inflammatory and immunomodulatory activities of PWE. In order to better understand the equilibrium between effectiveness and toxicity, which is essential for a new medicine, the characteristics of PWE were analyzed. We developed and validated an RP-HPLC method to chemically characterize PWE and PEE and evaluated the in vitro antioxidant/antimicrobial activity for both extracts and the safety of PWE via determining genotoxic potential using in vitro and in vivo mammalian micronucleus assays. We have concluded that the proposed analytical methodology was reliable, and both extracts showed similar chemical composition. The extracts presented antioxidant and antimicrobial effects, while PWE demonstrated higher antioxidant activity and more efficacious for the most of the microorganisms tested than PEE. Finally, PWE was shown to be safe using micronucleus assays. © 2013 Bruno Alves Rocha et al.en
dc.subjectanimal experiment-
dc.subjectantimicrobial activity-
dc.subjectantioxidant activity-
dc.subjectcontrolled study-
dc.subjectdrug efficacy-
dc.subjectdrug safety-
dc.subjectdrug screening-
dc.subjectin vitro study-
dc.subjectin vivo study-
dc.subjectmicronucleus test-
dc.subjectpriority journal-
dc.subjectreversed phase high performance liquid chromatography-
dc.titleEvaluation of a propolis water extract using a reliable RP-HPLC methodology and in vitro and in vivo efficacy and safety characterisationen
dc.contributor.institutionApis Flora Industrial e Comercial LTDA-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionParque Universitário-
dc.description.affiliationLaboratório de Pesquisa, Desenvolvimento e Inovação (P, D and I) Apis Flora Industrial e Comercial LTDA, Rua Triunfo, 945, 14020-670 Ribeirão Preto, SP-
dc.description.affiliationDepartamento de Química Faculdade de Filosofia Ciências e Letras de Ribeirão Preto Universidade de São Paulo, Avenida Bandeirantes, 3900, 14040-901 Ribeirão Preto, SP-
dc.description.affiliationInstituto de Química Universidade Estadual Paulista, Rua Francisco Degni, 55, 14800-900 Araraquara, SP-
dc.description.affiliationDepartamento de Ciências Farmacêuticas de Ribeirão Preto Universidade de São Paulo, Avenida do Café, s/n, 14040-903 Ribeirão Preto, SP-
dc.description.affiliationUniversidade de Franca Parque Universitário, Avenida Dr. Armando Salles de Oliveira, 201, 14404-600 Franca, SP-
dc.description.affiliationUnespInstituto de Química Universidade Estadual Paulista, Rua Francisco Degni, 55, 14800-900 Araraquara, SP-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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