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dc.contributor.authorDalmora, M. E.-
dc.contributor.authorDalmora, S. L.-
dc.contributor.authorOliveira, Anselmo Gomes de-
dc.identifier.citationInternational Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 222, n. 1, p. 45-55, 2001.-
dc.description.abstractTopical formulations of piroxicam were evaluated by determination of their in vitro release and in vivo anti-inflammatory effect. The in vitro release assay demonstrated that the microemulsion (ME) systems provided a reservoir effect for piroxicam release. However, the incorporation of the ME into carboxyvinilic gel provoked a greater reduction in the release of piroxicam than the ME system alone. Anti-inflammatory activity was carried out by the cotton pellet granuloma inhibition bioassay. Topical anti-inflammatory effect of the piroxicam inclusion complex/ME contained in carboxyvinilic gel showed significant inhibition of the inflammation process (36.9%, P < 0.05). Subcutaneous administration of the drug formulations showed a significant effect on the inhibition of inflammation, 68.8 and 70.5%, P <0.05, when the piroxicam was incorporated in ME and in the combined system beta -cyclodextrin (B-CD)/ME, respectively, relative to the buffered piroxicam (42.2%). These results demonstrated that the ME induced prolonged effects, providing inhibition of the inflammation for 9 days after a single dose administration. (C) 2001 Elsevier B.V. B.V. All rights reserved.en
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectanti-inflammatory effectpt
dc.subjectin vitro drug releasept
dc.titleInclusion complex of piroxicam with beta-cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in vivo topical anti-inflammatory effecten
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)-
dc.description.affiliationUNESP, Fac Ciências Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil-
dc.description.affiliationUniversidade Federal de Santa Maria (UFSM), Ctr Ciências Saude, Dept Farm Ind, BR-97119900 Santa Maria, RS, Brazil-
dc.description.affiliationUnespUNESP, Fac Ciências Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofInternational Journal of Pharmaceutics-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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