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DC Field | Value | Language |
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dc.contributor.author | Dalmora, M. E. | - |
dc.contributor.author | Dalmora, S. L. | - |
dc.contributor.author | Oliveira, Anselmo Gomes de | - |
dc.date.accessioned | 2014-05-20T13:24:23Z | - |
dc.date.accessioned | 2016-10-25T16:45:06Z | - |
dc.date.available | 2014-05-20T13:24:23Z | - |
dc.date.available | 2016-10-25T16:45:06Z | - |
dc.date.issued | 2001-07-03 | - |
dc.identifier | http://dx.doi.org/10.1016/S0378-5173(01)00692-5 | - |
dc.identifier.citation | International Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 222, n. 1, p. 45-55, 2001. | - |
dc.identifier.issn | 0378-5173 | - |
dc.identifier.uri | http://hdl.handle.net/11449/7543 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/7543 | - |
dc.description.abstract | Topical formulations of piroxicam were evaluated by determination of their in vitro release and in vivo anti-inflammatory effect. The in vitro release assay demonstrated that the microemulsion (ME) systems provided a reservoir effect for piroxicam release. However, the incorporation of the ME into carboxyvinilic gel provoked a greater reduction in the release of piroxicam than the ME system alone. Anti-inflammatory activity was carried out by the cotton pellet granuloma inhibition bioassay. Topical anti-inflammatory effect of the piroxicam inclusion complex/ME contained in carboxyvinilic gel showed significant inhibition of the inflammation process (36.9%, P < 0.05). Subcutaneous administration of the drug formulations showed a significant effect on the inhibition of inflammation, 68.8 and 70.5%, P <0.05, when the piroxicam was incorporated in ME and in the combined system beta -cyclodextrin (B-CD)/ME, respectively, relative to the buffered piroxicam (42.2%). These results demonstrated that the ME induced prolonged effects, providing inhibition of the inflammation for 9 days after a single dose administration. (C) 2001 Elsevier B.V. B.V. All rights reserved. | en |
dc.format.extent | 45-55 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | piroxicam | pt |
dc.subject | beta-cyclodextrin | pt |
dc.subject | microemulsion | pt |
dc.subject | anti-inflammatory effect | pt |
dc.subject | in vitro drug release | pt |
dc.title | Inclusion complex of piroxicam with beta-cyclodextrin and incorporation in cationic microemulsion. In vitro drug release and in vivo topical anti-inflammatory effect | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade Federal de Sergipe (UFS) | - |
dc.description.affiliation | UNESP, Fac Ciências Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil | - |
dc.description.affiliation | Universidade Federal de Santa Maria (UFSM), Ctr Ciências Saude, Dept Farm Ind, BR-97119900 Santa Maria, RS, Brazil | - |
dc.description.affiliationUnesp | UNESP, Fac Ciências Farmaceut, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil | - |
dc.identifier.doi | 10.1016/S0378-5173(01)00692-5 | - |
dc.identifier.wos | WOS:000169704300005 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | International Journal of Pharmaceutics | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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