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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75442
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dc.contributor.authorPerazzo, F. F.-
dc.contributor.authorRodrigues, I. V.-
dc.contributor.authorMaistro, Edson Luis-
dc.contributor.authorSouza, S. M.-
dc.contributor.authorNanaykkara, N. P. D.-
dc.contributor.authorBastos, J. K.-
dc.contributor.authorCarvalho, J. C. T.-
dc.contributor.authorSouza, G. H. B. de-
dc.date.accessioned2014-05-27T11:29:32Z-
dc.date.accessioned2016-10-25T18:48:38Z-
dc.date.available2014-05-27T11:29:32Z-
dc.date.available2016-10-25T18:48:38Z-
dc.date.issued2013-05-28-
dc.identifierhttp://dx.doi.org/10.1016/j.phcgj.2012.12.001-
dc.identifier.citationPharmacognosy Journal, v. 5, n. 1, p. 13-16, 2013.-
dc.identifier.issn0975-3575-
dc.identifier.urihttp://hdl.handle.net/11449/75442-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75442-
dc.description.abstractSome of the Piper species have been applied for the treatment of several diseases (anti-oxidant, antimicrobial, anti-inflammatory, and analgesic), considering multiple applications used in traditional medicine of different countries. About these, the present study evaluated some biological activities of Piper cubeba, as writhing test induced by acetic acid, ear edema induced by croton oil and paw edema induced by carrageenan were used by evaluated the analgesic and anti-inflammatory activities of crude hydroalcoholic extract (PCE) and its fractions of different polarities of P. cubeba L. seeds. The lethal dose (LD50) and the effective dose (ED50) were evaluated too. Both the PCE and dichloromethane fraction showed decrease values of edema and abdominal constrictions. The results obtained in this study confirm the low toxicity and analgesic and anti-inflammatory activities of PCE from P. cubeba seeds, justifying its use in folk medicine. Copyright © 2013, Phcog.Net, Published by Reed Elsevier India Pvt. Ltd. All rights reserved.en
dc.format.extent13-16-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAnalgesic-
dc.subjectAnti-inflammatory-
dc.subjectPiper cubeba-
dc.subjectPiperaceae-
dc.subjectacetic acid-
dc.subjectacetic acid ethyl ester-
dc.subjectalcohol-
dc.subjectanalgesic agent-
dc.subjectantiinflammatory agent-
dc.subjectcarrageenan-
dc.subjectcroton oil-
dc.subjectdexamethasone-
dc.subjectdichloromethane-
dc.subjecthexane-
dc.subjectindometacin-
dc.subjectPiper cubeba extract-
dc.subjectplant extract-
dc.subjectsodium chloride-
dc.subjectunclassified drug-
dc.subjectanalgesic activity-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectantiinflammatory activity-
dc.subjectcontrolled study-
dc.subjectdrug efficacy-
dc.subjectear edema-
dc.subjectLD 50-
dc.subjectmale-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpain-
dc.subjectpaw edema-
dc.subjectplant seed-
dc.subjectrat-
dc.subjectsingle drug dose-
dc.subjecttoxicity testing-
dc.subjectwrithing test-
dc.titleAnti-inflammatory and analgesic evaluation of hydroalcoholic extract and fractions from seeds of Piper cubeba L. (Piperaceae)en
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversity of Mississippi-
dc.contributor.institutionUniversidade Federal de Ouro Preto (UFOP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationFaculdade de Ciências Farmacêuticas de Ribeirão Preto USP, Ribeirão Preto, SP, CEP 14040-903-
dc.description.affiliationDepartamento de Ciências Exatas e da Terra UNIFESP, Diadema, SP, CEP 09972-270-
dc.description.affiliationNational Center for Natural Products Research School of Pharmacy University of Mississippi, MS 38677-
dc.description.affiliationLab. de Farmacognosia Escola de Farmácia UFOP, Ouro Preto, MG, CEP 35400-000-
dc.description.affiliationFaculdade de Filosofia e Ciências Departamento de Fonoaudiologia UNESP, Marília, SP, CEP 17525-900-
dc.description.affiliationUnespFaculdade de Filosofia e Ciências Departamento de Fonoaudiologia UNESP, Marília, SP, CEP 17525-900-
dc.identifier.doi10.1016/j.phcgj.2012.12.001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPharmacognosy Journal-
dc.identifier.scopus2-s2.0-84878054430-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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