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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/7546
Título: 
The effects of oral glutamine on cisplatin-induced nephrotoxicity in rats
Autor(es): 
Instituição: 
  • Universidade de São Paulo (USP)
  • Universidade Estadual Paulista (UNESP)
  • Fac Med Triangulo Mineiro
ISSN: 
1043-6618
Resumo: 
The antioxidant activity of the amino acid glutamine was investigated to obtain protection against peroxidative damage in rat kidney and nephrotoxicity induced by the treatment with a single dose of the antitumoral cisplatin (5 mg kg(-1) body weight). The animals were divided into four treatment and control groups of six rats each (n = 6). Cisplatin was injected i.p. and glutamine (300 mg kg(-1) body weight) was given by gavage 24 h before the cisplatin injection. After 24 h and 7 days of cisplatin administration, the rats were sacrificed. A single dose of cisplatin resulted in significant reduction in body weight and creatinine clearance, and higher urinary volumes were observed in all groups treated with this antitumor drug (P < 0.05). Renal tissue from cisplatin-treated rats showed an increase in malondialdehyde production and increase in glutathione contents 24 h and 7 days after cisplatin administration. Pretreatment of rats with glutamine substantially inhibited the increase in the levels of renal glutathione induced by cisplatin 24 h after the i.p. injection. The malondialdehyde, in the renal tissues was significantly reduced 7 days after cisplatin treatment. However, the reduction in the peroxidative damage did not reach the value of the control group. The protective effects obtained by glutamine pretreatment in peroxidative alterations were not observed in the other parameters studied. These results suggest that glutamine partially protect against cisplatin-induced lipid peroxidation damage, but it was not enough to inhibit cisplatin-induced nephrotoxicity in rats. (C) 2003 Elsevier B.V. Ltd. All rights reserved.
Data de publicação: 
1-Jun-2003
Citação: 
Pharmacological Research. London: Academic Press Ltd Elsevier B.V. Ltd, v. 47, n. 6, p. 517-522, 2003.
Duração: 
517-522
Publicador: 
Elsevier B.V.
Palavras-chaves: 
  • glutamine
  • cisplatin
  • nephrotoxicity
  • lipid peroxidation
Fonte: 
http://dx.doi.org/10.1016/S1043-6618(03)00040-9
Endereço permanente: 
Direitos de acesso: 
Acesso restrito
Tipo: 
outro
Fonte completa:
http://repositorio.unesp.br/handle/11449/7546
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