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dc.contributor.authorMora, L. D.-
dc.contributor.authorAntunes, LMG-
dc.contributor.authorFrancescato, H. D.-
dc.contributor.authorBianchi, MDP-
dc.identifier.citationPharmacological Research. London: Academic Press Ltd Elsevier B.V. Ltd, v. 47, n. 6, p. 517-522, 2003.-
dc.description.abstractThe antioxidant activity of the amino acid glutamine was investigated to obtain protection against peroxidative damage in rat kidney and nephrotoxicity induced by the treatment with a single dose of the antitumoral cisplatin (5 mg kg(-1) body weight). The animals were divided into four treatment and control groups of six rats each (n = 6). Cisplatin was injected i.p. and glutamine (300 mg kg(-1) body weight) was given by gavage 24 h before the cisplatin injection. After 24 h and 7 days of cisplatin administration, the rats were sacrificed. A single dose of cisplatin resulted in significant reduction in body weight and creatinine clearance, and higher urinary volumes were observed in all groups treated with this antitumor drug (P < 0.05). Renal tissue from cisplatin-treated rats showed an increase in malondialdehyde production and increase in glutathione contents 24 h and 7 days after cisplatin administration. Pretreatment of rats with glutamine substantially inhibited the increase in the levels of renal glutathione induced by cisplatin 24 h after the i.p. injection. The malondialdehyde, in the renal tissues was significantly reduced 7 days after cisplatin treatment. However, the reduction in the peroxidative damage did not reach the value of the control group. The protective effects obtained by glutamine pretreatment in peroxidative alterations were not observed in the other parameters studied. These results suggest that glutamine partially protect against cisplatin-induced lipid peroxidation damage, but it was not enough to inhibit cisplatin-induced nephrotoxicity in rats. (C) 2003 Elsevier B.V. Ltd. All rights reserved.en
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectlipid peroxidationpt
dc.titleThe effects of oral glutamine on cisplatin-induced nephrotoxicity in ratsen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionFac Med Triangulo Mineiro-
dc.description.affiliationUniv São Paulo, Fac Ciências Farmaceut, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Ciências Farmaceut, Araraquara, SP, Brazil-
dc.description.affiliationFac Med Triangulo Mineiro, Dept Ciências Biol, BR-38025050 Uberaba, MG, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciências Farmaceut, Araraquara, SP, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPharmacological Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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