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dc.contributor.authorZeidán-Chuliá, Fares-
dc.contributor.authorRybarczyk-Filho, José Luiz-
dc.contributor.authorSalmina, Alla B.-
dc.contributor.authorDe Oliveira, Ben-Hur Neves-
dc.contributor.authorNoda, Mami-
dc.contributor.authorMoreira, José Cláudio F.-
dc.identifier.citationNeuroMolecular Medicine, v. 15, n. 2, p. 364-383, 2013.-
dc.description.abstractAutism is a neurodevelopmental disorder characterized by impaired social interaction and communication accompanied with repetitive behavioral patterns and unusual stereotyped interests. Autism is considered a highly heterogeneous disorder with diverse putative causes and associated factors giving rise to variable ranges of symptomatology. Incidence seems to be increasing with time, while the underlying pathophysiological mechanisms remain virtually uncharacterized (or unknown). By systematic review of the literature and a systems biology approach, our aims were to examine the multifactorial nature of autism with its broad range of severity, to ascertain the predominant biological processes, cellular components, and molecular functions integral to the disorder, and finally, to elucidate the most central contributions (genetic and/or environmental) in silico. With this goal, we developed an integrative network model for gene-environment interactions (GENVI model) where calcium (Ca2+) was shown to be its most relevant node. Moreover, considering the present data from our systems biology approach together with the results from the differential gene expression analysis of cerebellar samples from autistic patients, we believe that RAC1, in particular, and the RHO family of GTPases, in general, could play a critical role in the neuropathological events associated with autism. © 2013 Springer Science+Business Media New York.en
dc.subjectAutism spectrum disorders-
dc.subjectGene expression-
dc.subjectIn silico model-
dc.subjectprotein Cdc42-
dc.subjectRac protein-
dc.subjectRac1 protein-
dc.subjectRhoA guanine nucleotide binding protein-
dc.subjectactin filament-
dc.subjectcalcium signaling-
dc.subjectenvironmental stress-
dc.subjectgene expression-
dc.subjectgenetic susceptibility-
dc.subjectgenotype environment interaction-
dc.subjectmicroarray analysis-
dc.subjectnerve cell plasticity-
dc.subjectpriority journal-
dc.subjectsystematic review-
dc.subjectsystems biology-
dc.titleExploring the multifactorial nature of autism through computational systems biology: Calcium and the Rho GTPase RAC1 under the spotlighten
dc.contributor.institutionFederal University of Rio Grande Do sul-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionKrasnoyarsk State Medical University-
dc.contributor.institutionKyushu University-
dc.description.affiliationDepartment of Biochemistry Center of Oxidative Stress Research Federal University of Rio Grande Do sul, Porto Alegre, RS-
dc.description.affiliationDepartamento de Física e Biofísica Instituto de Biociências de Botucatu Universidade Estadual Paulista (UNESP), Botucatu, SP-
dc.description.affiliationDepartment of Biochemistry, Medical, Pharmaceutical and Toxicological Chemistry Krasnoyarsk State Medical University, Krasnoyarsk-
dc.description.affiliationLaboratory of Pathophysiology Graduate School of Pharmaceutical Sciences Kyushu University, Fukuoka-
dc.description.affiliationUnespDepartamento de Física e Biofísica Instituto de Biociências de Botucatu Universidade Estadual Paulista (UNESP), Botucatu, SP-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofNeuroMolecular Medicine-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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