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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75508
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dc.contributor.authorZena, Lucas A.-
dc.contributor.authorGargaglioni, Luciane H.-
dc.contributor.authorBícego, Kênia C.-
dc.date.accessioned2014-05-27T11:29:34Z-
dc.date.accessioned2016-10-25T18:48:55Z-
dc.date.available2014-05-27T11:29:34Z-
dc.date.available2016-10-25T18:48:55Z-
dc.date.issued2013-06-01-
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2013.03.020-
dc.identifier.citationComparative Biochemistry and Physiology - A Molecular and Integrative Physiology, v. 165, n. 2, p. 263-271, 2013.-
dc.identifier.issn1095-6433-
dc.identifier.issn1531-4332-
dc.identifier.urihttp://hdl.handle.net/11449/75508-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75508-
dc.description.abstractThe goal of the present study was to determine if nitric oxide (NO) acting on the brain of bullfrog (Lithobates catesbeianus) is involved in arterial pressure and heart rate (HR) control by influencing sympathetic activity. We investigated the effect of intracerebroventricular injections of l-NMMA (a nonselective NO synthase inhibitor) on mean arterial blood pressure (MAP), HR and cutaneous vascular conductance (CVC) of pelvic skin after intravenous injection of α or β adrenergic blockers, prazosin or sotalol, respectively. Arterial pressure was directly measured by a telemetry sensor inserted in the aortic arch of animals. l-NMMA increased MAP, but did not change HR. This hypertensive response was inhibited by the pre-treatment with prazosin, but accentuated by sotalol. The effect of l-NMMA on MAP was also inhibited by i.v. injections of the ganglionic blocker, hexamethonium. Thus, NO acting on the brain of bullfrog seems to present a hypotensive effect influencing the sympathetic activity dependent on α and β adrenergic receptors in the periphery. © 2013 Elsevier Inc.en
dc.format.extent263-271-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectAdrenergic receptors-
dc.subjectL-NMMA-
dc.subjectPrazosin-
dc.subjectSotalol-
dc.subjectTelemetry-
dc.subjectalpha adrenergic receptor-
dc.subjectbeta adrenergic receptor-
dc.subjecthexamethonium-
dc.subjectn(g) methylarginine-
dc.subjectnitric oxide-
dc.subjectprazosin-
dc.subjectsotalol-
dc.subjectaorta arch-
dc.subjectarterial pressure-
dc.subjectbody temperature-
dc.subjectbrain-
dc.subjectbullfrog-
dc.subjectcardiovascular system-
dc.subjectdiastolic blood pressure-
dc.subjectheart rate-
dc.subjectmean arterial pressure-
dc.subjectnonhuman-
dc.subjectskin blood vessel-
dc.subjectsympathetic tone-
dc.subjectsystolic blood pressure-
dc.subjecttelemetry-
dc.titleRole of brain nitric oxide in the cardiovascular control of bullfrogsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionINCT-Fisiologia Comparada-
dc.description.affiliationDepartment of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900-
dc.description.affiliationNational Inst. of Science and Technology on Comparative Physiology INCT-Fisiologia Comparada-
dc.description.affiliationUnespDepartment of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900-
dc.identifier.doi10.1016/j.cbpa.2013.03.020-
dc.identifier.wosWOS:000319233300019-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84876345696.pdf-
dc.relation.ispartofComparative Biochemistry and Physiology - A Molecular and Integrative Physiology-
dc.identifier.scopus2-s2.0-84876345696-
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