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DC Field | Value | Language |
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dc.contributor.author | Zena, Lucas A. | - |
dc.contributor.author | Gargaglioni, Luciane H. | - |
dc.contributor.author | Bícego, Kênia C. | - |
dc.date.accessioned | 2014-05-27T11:29:34Z | - |
dc.date.accessioned | 2016-10-25T18:48:55Z | - |
dc.date.available | 2014-05-27T11:29:34Z | - |
dc.date.available | 2016-10-25T18:48:55Z | - |
dc.date.issued | 2013-06-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.cbpa.2013.03.020 | - |
dc.identifier.citation | Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, v. 165, n. 2, p. 263-271, 2013. | - |
dc.identifier.issn | 1095-6433 | - |
dc.identifier.issn | 1531-4332 | - |
dc.identifier.uri | http://hdl.handle.net/11449/75508 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/75508 | - |
dc.description.abstract | The goal of the present study was to determine if nitric oxide (NO) acting on the brain of bullfrog (Lithobates catesbeianus) is involved in arterial pressure and heart rate (HR) control by influencing sympathetic activity. We investigated the effect of intracerebroventricular injections of l-NMMA (a nonselective NO synthase inhibitor) on mean arterial blood pressure (MAP), HR and cutaneous vascular conductance (CVC) of pelvic skin after intravenous injection of α or β adrenergic blockers, prazosin or sotalol, respectively. Arterial pressure was directly measured by a telemetry sensor inserted in the aortic arch of animals. l-NMMA increased MAP, but did not change HR. This hypertensive response was inhibited by the pre-treatment with prazosin, but accentuated by sotalol. The effect of l-NMMA on MAP was also inhibited by i.v. injections of the ganglionic blocker, hexamethonium. Thus, NO acting on the brain of bullfrog seems to present a hypotensive effect influencing the sympathetic activity dependent on α and β adrenergic receptors in the periphery. © 2013 Elsevier Inc. | en |
dc.format.extent | 263-271 | - |
dc.language.iso | eng | - |
dc.source | Scopus | - |
dc.subject | Adrenergic receptors | - |
dc.subject | L-NMMA | - |
dc.subject | Prazosin | - |
dc.subject | Sotalol | - |
dc.subject | Telemetry | - |
dc.subject | alpha adrenergic receptor | - |
dc.subject | beta adrenergic receptor | - |
dc.subject | hexamethonium | - |
dc.subject | n(g) methylarginine | - |
dc.subject | nitric oxide | - |
dc.subject | prazosin | - |
dc.subject | sotalol | - |
dc.subject | aorta arch | - |
dc.subject | arterial pressure | - |
dc.subject | body temperature | - |
dc.subject | brain | - |
dc.subject | bullfrog | - |
dc.subject | cardiovascular system | - |
dc.subject | diastolic blood pressure | - |
dc.subject | heart rate | - |
dc.subject | mean arterial pressure | - |
dc.subject | nonhuman | - |
dc.subject | skin blood vessel | - |
dc.subject | sympathetic tone | - |
dc.subject | systolic blood pressure | - |
dc.subject | telemetry | - |
dc.title | Role of brain nitric oxide in the cardiovascular control of bullfrogs | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | INCT-Fisiologia Comparada | - |
dc.description.affiliation | Department of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900 | - |
dc.description.affiliation | National Inst. of Science and Technology on Comparative Physiology INCT-Fisiologia Comparada | - |
dc.description.affiliationUnesp | Department of Animal Morphology and Physiology College of Agricultural and Veterinarian Sciences São Paulo State University, Jaboticabal, São Paulo 14884-900 | - |
dc.identifier.doi | 10.1016/j.cbpa.2013.03.020 | - |
dc.identifier.wos | WOS:000319233300019 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.identifier.file | 2-s2.0-84876345696.pdf | - |
dc.relation.ispartof | Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology | - |
dc.identifier.scopus | 2-s2.0-84876345696 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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