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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/75512
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dc.contributor.authorPeres, Raphael Sanches-
dc.contributor.authorChiuso-Minicucci, Fernanda-
dc.contributor.authorda Rosa, Larissa Camargo-
dc.contributor.authorDomingues, Alexandre-
dc.contributor.authorZorzella-Pezavento, Sofia Fernanda Gonçalves-
dc.contributor.authorFrança, Thais Graziela Donegá-
dc.contributor.authorIshikawa, Larissa Lumi Watanabe-
dc.contributor.authordo Amarante, Alessandro Francisco Talamini-
dc.contributor.authorSartori, Alexandrina-
dc.date.accessioned2014-05-27T11:29:34Z-
dc.date.accessioned2016-10-25T18:48:55Z-
dc.date.available2014-05-27T11:29:34Z-
dc.date.available2016-10-25T18:48:55Z-
dc.date.issued2013-06-01-
dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2013.03.007-
dc.identifier.citationExperimental Parasitology, v. 134, n. 2, p. 183-189, 2013.-
dc.identifier.issn0014-4894-
dc.identifier.issn1090-2449-
dc.identifier.urihttp://hdl.handle.net/11449/75512-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/75512-
dc.description.abstractEpidemiological and experimental studies support the idea that helminth infections can induce a protective effect against the development of autoimmune and allergic diseases. In this study we characterized the immune response induced by Strongyloides venezuelensis infection in C57BL/6 mice and then evaluated the effect of a previous contact with this helminth in the outcome of type 1 diabetes. Animals were initially infected with 2000 L3 larvae from S. venezuelensis and euthanized 22. days later. An acute phase, identified by a high amount of eggs per gram of feces, was established between days 7 and 9 post-infection. Recovery from infection was associated with a Th2 polarized response characterized by a significant level of serum IgG1 specific antibodies and also a significant production of IL-5 and IL-10 by spleen cells stimulated with S. venezuelensis soluble antigen. Immunization with soluble S. venezuelensis antigen associated with complete Freund's adjuvant followed by infection with S. venezuelensis protected mice from diabetes development induced by streptozotocin. Protection was characterized by a higher body weight gain, lower glycemic levels, much less severe insulitis and preserved insulin production. Together, these results indicate that S. venezuelensis contributed to protect C57BL/6 mice against experimental diabetes induced by streptozotocin. © 2013 Elsevier Inc.en
dc.format.extent183-189-
dc.language.isoeng-
dc.sourceScopus-
dc.subjectExperimental diabetes-
dc.subjectHygiene hypothesis-
dc.subjectS. venezuelensis-
dc.subjectStreptozotocin-
dc.subjectFreund adjuvant-
dc.subjectgamma interferon-
dc.subjectimmunoglobulin G1-
dc.subjectinsulin-
dc.subjectinterleukin 10-
dc.subjectinterleukin 5-
dc.subjectparasite antigen-
dc.subjectStrongyloides venezuelensis antigen-
dc.subjectunclassified drug-
dc.subjectanimal experiment-
dc.subjectanimal model-
dc.subjectanimal tissue-
dc.subjectbody weight-
dc.subjectcontrolled study-
dc.subjectcytokine production-
dc.subjectdrug efficacy-
dc.subjectimmune response-
dc.subjectimmunization-
dc.subjectimmunoglobulin blood level-
dc.subjectimmunomodulation-
dc.subjectinsulin dependent diabetes mellitus-
dc.subjectinsulitis-
dc.subjectmale-
dc.subjectmouse-
dc.subjectnonhuman-
dc.subjectpriority journal-
dc.subjectspleen cell-
dc.subjectStrongyloides venezuelensis-
dc.subjectstrongyloidiasis-
dc.subjecttreatment response-
dc.subjectweight reduction-
dc.subjectAnimals-
dc.subjectAntibodies, Helminth-
dc.subjectBlood Glucose-
dc.subjectCytokines-
dc.subjectDiabetes Mellitus, Experimental-
dc.subjectDiabetes Mellitus, Type 1-
dc.subjectFeces-
dc.subjectInsulin-
dc.subjectIslets of Langerhans-
dc.subjectMale-
dc.subjectMice-
dc.subjectMice, Inbred C57BL-
dc.subjectParasite Egg Count-
dc.subjectRats-
dc.subjectRats, Wistar-
dc.subjectSpleen-
dc.subjectStreptozocin-
dc.subjectStrongyloides-
dc.subjectStrongyloidiasis-
dc.subjectTh2 Cells-
dc.titlePrevious contact with Strongyloides venezuelensis contributed to prevent insulitis in MLD-STZ diabetesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationDepartment of Microbiology and Immunology Biosciences Institute, Univ Estadual Paulista (UNESP), Botucatu, São Paulo-
dc.description.affiliationDepartment of Pathology Botucatu Medical School Univ Estadual Paulista (UNESP), Botucatu, São Paulo-
dc.description.affiliationDepartment of Parasitology Biosciences Institute Univ Estadual Paulista (UNESP), Botucatu, São Paulo-
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School Univ Estadual Paulista (UNESP), Botucatu, São Paulo-
dc.description.affiliationUnespDepartment of Parasitology Biosciences Institute Univ Estadual Paulista (UNESP), Botucatu, São Paulo-
dc.identifier.doi10.1016/j.exppara.2013.03.007-
dc.identifier.wosWOS:000319542800010-
dc.rights.accessRightsAcesso aberto-
dc.identifier.file2-s2.0-84876318616.pdf-
dc.relation.ispartofExperimental Parasitology-
dc.identifier.scopus2-s2.0-84876318616-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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